Partial protective effect of inactivated Japanese encephalitis vaccine on lethal West Nile virus infection in mice
Partial protective effect of inactivated Japanese encephalitis vaccine on lethal West Nile virus infection in mice
复制标题
DOI：
10.1016/s0264-410x(03)00507-3
复制
发表时间：
2003-11-07
期刊：
影响因子：
5.5
通讯作者：
Kurane, I
中科院分区：
文献类型：
--
作者：
Takasaki, T;Yabe, S;Kurane, I
使用小鼠模型检测了小鼠脑源性灭活乙型脑炎（JE）疫苗对西尼罗河病毒（WNV）感染的影响。用乙脑疫苗免疫小鼠两次，并用致死剂量的西尼罗河病毒攻击。当用WNV颅内攻击小鼠时，没有一只免疫小鼠受到保护。腹腔内攻击时，免疫小鼠在较高的免疫水平下获得保护。乙脑疫苗免疫可诱导产生抗西尼罗河病毒的交叉中和抗体，但水平远低于乙脑病毒。这些结果表明，目前可用的小鼠脑源性灭活乙脑疫苗可以诱导小鼠对西尼罗河病毒的部分保护性免疫。(C)2003 Elsevier Ltd.保留所有权利。
The effect of mouse brain-derived, inactivated Japanese encephalitis (JE) vaccine on West Nile virus (WNV) infection was examined using a murine model. Mice were immunized with JE vaccine twice and challenged with lethal doses of WNV. When mice were intracranially challenged with WNV, none of the immunized mice were protected. When mice were intraperitoneally challenged, the immunized mice were protected at higher immunization levels. Cross-reactive neutralizing antibodies to WNV were induced by immunization with JE vaccine; however, the levels were much lower than those to JEV. These results indicate that the currently available mouse brain-derived inactivated JE vaccine can induce partial protective immunity to WNV in mice. (C) 2003 Elsevier Ltd. All rights reserved.