Brain magnetic resonance diffusion abnormalities in Creutzfeldt-Jakob disease
Brain magnetic resonance diffusion abnormalities in Creutzfeldt-Jakob disease
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DOI：
10.1001/archneur.1997.00550230078021
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发表时间：
1997-11-01
影响因子：
--
通讯作者：
Pearlman, AL
中科院分区：
文献类型：
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作者：
Bahn, MM;Kido, DK;Pearlman, AL
背景：大脑磁共振成像在克雅氏病的诊断中作用有限。已经描述了 T-2 加权图像的异常，但这些异常既不高度敏感，也不具有特异性。目的：确定扩散加权磁共振图像是否可用于评估克雅氏病。病例介绍：一名患有快速进展性痴呆的 61 岁女性被转诊进行颅磁共振成像。作为检查的一部分获得弥散加权图像。脑活检在组织学上证实了克雅氏病的诊断。结果和结论：弥散加权磁共振脑图像显示双侧对称的尾状核、壳核、丘脑、扣带回和右额下皮质的信号强度显着增加。表观扩散系数图显示这些区域的扩散异常低（尾状头部低至正常值的 40%）。这表明这些区域的扩散受到限制。 T-2 加权图像显示尾状核和壳核的双侧信号略有增加。这些发现表明，扩散磁共振成像可能是对克雅氏病异常进行成像的敏感方法。
Background: Magnetic resonance imaging of the brain has been of limited usefulness in the diagnosis of Creutzfeldt-Jakob disease. Abnormalities on T-2-weighted images have been described, but these are neither highly sensitive nor specific.Objective: To determine whether diffusion-weighted magnetic resonance images might be useful in the evaluation of Creutzfeldt-Jakob disease.Case Presentation: A 61-year-old woman with rapidly progressive dementia was referred for cranial magnetic resonance imaging. Diffusion-weighted images were obtained as part of the examination. Brain biopsy confirmed the diagnosis of Creutzfeldt-Jakob disease histologically.Findings and Conclusions: The diffusion-weighted magnetic resonance brain images demonstrated bilaterally symmetrical marked increase in signal intensity in the caudate nuclei, putamina, thalami, cingulate gyri, and right inferior frontal cortex. The apparent diffusion coefficient map showed abnormally low diffusion in these regions (as low as 40% of normal in the caudate head). This suggests that there is restricted diffusion in these regions. The T-2-weighted images demonstrated slightly increased signal bilaterally in the caudate nuclei and putamina. These findings indicate that diffusion magnetic resonance imaging might be a sensitive means of imaging the abnormalities seen in Creutzfeldt-Jakob disease.