Stressful Life Events and Smoking Were Associated With Graves' Disease in Women, but Not in Men
Stressful Life Events and Smoking Were Associated With Graves' Disease in Women, but Not in Men
复制标题
压力生活事件和吸烟与女性格雷夫斯病有关，但与男性无关
作者：
K. Yoshiuchi;Hiroaki Kumano;S. Nomura;H. Yoshimura;K. Ito;Y. Kanaji;Y. Ohashi;T. Kuboki;H. Suematsu
目的虽然心理应激和吸烟已被认为是Graves病的促发因素，但它们在Graves病发病机制中的独立作用尚未确定。我们通过多变量分析评估了Graves病与心理压力和吸烟之间的关系。方法采用配对病例对照研究方法，对228例初治Graves病患者（女性182例，男性46例）的应激性生活事件、日常生活琐事、吸烟、饮酒习惯、应对技能、社会支持等与Graves病的关系进行调查，采用条件最大似然法。结果在调整日常生活琐事、吸烟、饮酒习惯、社会支持和应对技能后，我们发现压力性生活事件与女性Graves病的风险显著相关。压力最高的女性与压力最低的女性相比，相对风险为7.7（95%置信区间为2.2至27，p <0.001）。吸烟也与女性格雷夫斯病的风险独立相关。吸烟人数最多的女性与吸烟人数最少的女性相比，相对风险为5.1（95%置信区间为1.0至27;趋势p <0.001）。这些因素与男性Graves病无显著相关性。结论心理应激和吸烟与女性Graves病有关，而与男性无关。
Objective Although psychological stress and smoking have been proposed as contributing factors to Graves' disease, their independent roles in the pathogenesis of this disease have not been determined. We assessed the association between Graves' disease and psychological stress and smoking by using multivariate analysis. Methods By a matched case-control method, we investigated the association between Graves' disease and stressful life events, daily hassles, smoking, drinking habits, coping skills, and social support in 228 patients (182 women and 46 men) with newly diagnosed Graves' disease; we used the conditional maximum likelihood method. Results After data were adjusted for daily hassles, smoking, drinking habits, social support, and coping skills, we found that stressful life events were significantly associated with the risk of Graves' disease in women. The relative risk was 7.7 for women with the highest stress score compared with women with the lowest stress score (95% confidence interval, 2.2 to 27, p for trend < .001). Smoking was also independently associated with the risk of Graves' disease in women. The relative risk for women with the highest number group compared with women with the lowest number group for smoking cigarettes was 5.1 (95% confidence interval, 1.0 to 27; p for trend < .001). These factors were not significantly associated with Graves' disease in men. Conclusions Psychological stress and smoking were associated with Graves' disease in women, but not in men.
DOI：
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发表时间：
1988
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Sthoeger,ZM;Chiorazzi,N;Lahita,RG
通讯作者：
Lahita,RG