Cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G-->T) polymorphism is associated with phenotypes of metabolic syndrome in Japanese men.
Cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G-->T) polymorphism is associated with phenotypes of metabolic syndrome in Japanese men.
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DOI：
10.1016/j.metabol.2007.11.011
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发表时间：
2008-04
期刊：
影响因子：
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通讯作者：
Ling Zhang;K. Miyaki;T. Nakayama;M. Muramatsu
中科院分区：
文献类型：
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作者：
Ling Zhang;K. Miyaki;T. Nakayama;M. Muramatsu
细胞死亡诱导DNA片段化因子α样效应子A（CIDEA）调节脂肪组织中的能量消耗，并与肥胖的发生有关。CIDEA基因中的一个单核苷酸多态性导致缬氨酸115被C（V115 F）取代，最近已被证明与瑞典人群中的肥胖症有关。在这里，我们确定了这种多态性对日本人群代谢综合征表型的影响。二百七十无关的日本男性工人（平均年龄，44.5岁）进行了分析的横断面研究。确定每个个体的代谢综合征临床特征以及CIDEA V115 F多态性。V115 F基因多态性与腰围和空腹血糖相关VF + FF组的这些参数水平高于VV组（P <0.05）。与VV组相比，VF + FF组腹部肥胖（比值比[OR] = 1.89; 95%置信区间[CI]，1.03-3.44）、空腹血糖升高（OR = 2.81; 95% CI，1.03-7.67）和代谢综合征（OR = 3.15; 95% CI，1.05-9.48）的患病率更高。这些结果表明，CIDEA基因的F等位基因可能是日本男性代谢综合征相关表型的危险因素。
Cell death–inducing DNA fragmentation factor α–like effector A (CIDEA) regulates energy expenditure in the adipose tissue and is implicated in the development of obesity. A single nucleotide polymorphism in the CIDEA gene that causes an amino acid substitution of valine 115 to c(V115F) has recently been shown to be associated with obesity in the Swedish population. Here, we determined the effects of this polymorphism on phenotypes of metabolic syndrome within the Japanese population. Two hundred seventy unrelated Japanese male workers (mean age, 44.5 years) were analyzed in a cross-sectional study. The clinical features regarding metabolic syndrome, as well as CIDEA V115F polymorphism, were determined for each individual. The V115F polymorphism associated with waist circumference and fasting plasma glucose. These parameters were at higher levels in the VF + FF group than in the VV group (P < .05). The VF + FF group compared with the VV group had a higher prevalence for abdominal obesity (odds ratio [OR] = 1.89; 95% confidence interval [CI], 1.03-3.44), high fasting plasma glucose (OR = 2.81; 95% CI, 1.03-7.67), and metabolic syndrome (OR = 3.15; 95% CI, 1.05-9.48). These results suggest that the F allele of the CIDEA gene may serve as a risk factor for phenotypes related to metabolic syndrome in Japanese men.