Calmodulin-binding proteins as calpain substrates.
Calmodulin-binding proteins as calpain substrates.
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钙调蛋白结合蛋白作为钙蛋白酶底物。
DOI：
10.1042/bj2620693
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Basil D. Roufogalis
中科院分区：
文献类型：
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作者：
Kevin K. W. Wang;A. Villalobo;Basil D. Roufogalis
钙依赖性中性蛋白酶，也称为钙蛋白酶，近年来引起了越来越多的兴趣。其特性包括对 Ca2L 活性的绝对依赖性（钙蛋白酶 I 和钙蛋白酶 II 分别为微摩尔和毫摩尔浓度的 Ca2L），以及 7 至 8 之间的最佳 pH 值。它是从各种动物组织或细胞的胞质部分中分离出来的，但在某些条件下可能会转移到细胞膜上（有关先前的评论，请参见 Murachi，1983a；Zimmer-
Calcium-dependent neutral protease, also called calpain, has attracted increased interest in recent years. Its properties include an absolute dependence on Ca2l for activity (micromolar and millimolar concentrations of Ca2l for calpain I and calpain II, respectively), and a pH optimum between 7 and 8. It is isolated from the cytosolic fraction of various animal tissues or cells but it may be translocated to the cell membrane under certain conditions (for previous reviews see Murachi, 1983a; Zimmer-