Artemisinins inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense in vitro growth
Artemisinins inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense in vitro growth
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DOI：
10.1128/aac.01544-06
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发表时间：
2007-05-01
影响因子：
4.9
通讯作者：
Meade, John C.
中科院分区：
文献类型：
--
作者：
Mishina, Yuliya V.;Krishna, Sanjeev;Meade, John C.
青蒿素化合物在低微摩尔范围内的浓度下抑制培养的克氏锥虫和布氏锥虫罗得西亚的体外生长。青蒿素还能抑制T. Cruzi膜，表明通过膜泵的作用模式。青蒿素作为这些病原体的化疗选择值得进一步研究。
Artemisinin compounds inhibit in vitro growth of cultured Trypanosoma cruzi and Trypanosoma brucei rhodesiense at concentrations in the low micromolar range. Artemisinin also inhibits calcium-dependent ATPase activity in T. cruzi membranes, suggesting a mode of action via membrane pumps. Artemisinins merit further investigation as chemotherapeutic options for these pathogens.