Probiotic Potential of Lactobacillus Species in Allergic Rhinitis
Probiotic Potential of Lactobacillus Species in Allergic Rhinitis
复制标题
乳酸菌在过敏性鼻炎中的益生潜力
DOI：
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发表时间：
2021
影响因子：
2.8
通讯作者：
A. Lorentz
中科院分区：
文献类型：
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作者：
Nicole Steiner;A. Lorentz
由于治疗哮喘或过敏性鼻炎（AR）的传统过敏药物可能会产生副作用，从而限制患者的生活质量，因此寻找其他形式的治疗方法很有意义。特别是益生菌，例如乳酸菌，在各种小鼠和人类研究中已显示出抗过敏作用。例如，服用某些乳酸菌可以缓解鼻炎和眼部症状，并改善患有鼻炎的儿童和成人的生活质量。在人类和小鼠研究中都发现了细胞因子谱的不同变化，例如 Th1 细胞因子升高和 Th2 细胞因子减少、过敏相关免疫球蛋白减少和细胞迁移。口服乳酸菌后，还描述了对患者的积极影响，例如活动限制减少或鼻炎发作减少以及更长的时间没有哮喘或鼻炎。然而，目前尚不清楚这种乳酸菌如何导致免疫系统发生变化，从而抑制过敏的发展或缓解症状。本综述概述了当前的研究，并得出了有关益生菌乳杆菌菌株在 AR 中的使用的结论。
Since conventional allergy medication for asthma or allergic rhinitis (AR) can cause side effects which limit the patients’ quality of life, it is of interest to find other forms of therapy. In particular, probiotic bacteria, such as Lactobacillus species, have shown anti-allergic effects in various mouse and human studies. For instance, administration of some Lactobacillus species resulted in nasal and ocular symptom relief and improvement of quality of life in children and adults suffering from rhinitis. Different changes in cytokine profiles, such as elevated Th1 and decreased Th2 cytokines, reduced allergy-related immunoglobulins and cell immigration have been found in both human and murine studies. Positive effects on patients like less activity limitations or fewer rhinitis episodes and longer periods free from asthma or rhinitis were also described following oral administration of Lactobacillus bacteria. However, it is still unclear how this type of lactic acid bacteria leads to changes in the immune system and thus inhibits the development of allergies or relieves their symptoms. This review gives an overview of current studies and draws conclusions concerning the usage of probiotic Lactobacillus strains in AR.
DOI：
10.1073/pnas.0500098102
发表时间：
2005-02-22
影响因子：
11.1
作者：
Mohamadzadeh, M;Olson, S;Klaenhammer, TR
通讯作者：
Klaenhammer, TR