Vaginal cornification in persistent-estrous mice.
Vaginal cornification in persistent-estrous mice.
复制标题
持续发情小鼠的阴道角化。
DOI：
10.1210/endo-72-4-607
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发表时间：
1963
期刊：
影响因子：
4.8
通讯作者：
N. Takasugi
中科院分区：
文献类型：
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作者：
N. Takasugi
A/Crg1小鼠从出生后第1天开始每日注射雌激素诱导持续发情，连续5天。卵巢切除、卵巢切除加肾上腺切除、卵巢切除加垂体切除并不能阻止这些持续发情的小鼠阴道的持续角化。组胺和/或5-羟色胺对去卵巢正常小鼠的阴道角化无明显影响，对去卵巢持续发情小鼠的阴道角化也无影响。将持续发情的阴道移植到去卵巢的持续发情的小鼠和去卵巢的正常小鼠身上，并不能抑制50-60%的阴道移植物的角化。注射大量类固醇激素(黄体酮、皮质醇、脱氧皮质酮、睾酮)可阻止20%-40%的去卵巢持续发情小鼠阴道角化。另一方面，去卵巢的持续性发情小鼠中有20-40%的小鼠接受了黄体酮的治疗。
Persistent estrus was induced in A/Crgl mice by injections of estrogen daily for 5 days, starting on the 1st postnatal day. Ovariectomy, ovariectomy plus adrenalectomy, and ovariectomy plus hypophysectomy did not prevent the continuous cornification of vaginae in these persistent-estrous mice. Intraperitoneal or intravaginal administration of histamine and/or serotonin did not induce vaginal cornification in ovariectomized normal mice, and antihistamine had no influence on the vaginal cornification in ovariectomized persistent-estrous mice. Transplantation of the persistent-estrous vagina into ovariectomized persistent-estrous and into ovariectomized normal mice did not suppress cornification in 50–60 % of the vaginal transplants. Injection of large amounts of steroid hormones (progesterone, cortisol, deoxycorticosterone, testosterone) prevented vaginal cornification in 20–40 % of the ovariectomized persistent-estrous mice. On the other hand, 20–40% of the ovariectomized persistentestrous mice treated wit...