PROLACTIN IS A TUMOR PROMOTER IN RAT-LIVER
PROLACTIN IS A TUMOR PROMOTER IN RAT-LIVER
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DOI：
10.1016/0024-3205(85)90616-2
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发表时间：
1985-01-01
期刊：
影响因子：
6.1
通讯作者：
RUSSELL, DH
中科院分区：
文献类型：
--
作者：
BUCKLEY, AR;PUTNAM, CW;RUSSELL, DH
由于催乳素，如肿瘤促进剂12-O-十四酰基-佛波醇-13-乙酸酯，诱导鸟氨酸脱羧酶和纤溶酶原激活剂活性，营养反应的生化标志物，这种激素可能同样促进肿瘤形成。为了验证这一理论，大鼠开始与肝癌，随后6周的羊催乳素。该方案引起肝肿大和酶改变病灶的发展。催乳素促进23周进一步增加了酶改变灶的数量。我们认为，催乳素是一种内源性肿瘤的化学启动细胞的促进剂。
Since prolactin, like the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate, induces ornithine decarboxylase and plasminogen activator activities, biochemical markers of a trophic response, this hormone might likewise promote neoplasia. To test this theory, rats were initiated with a hepatocarcinogen followed by six weeks of ovine prolactin. This regimen caused hepatomegaly and the development of enzyme-altered foci. Promotion with prolactin for 23 weeks further increased the numbers of enzyme-altered foci. We suggest that prolactin is an endogenous tumor promoter for chemically initiated cells.