Depression and C-reactive protein in US adults - Data from the Third National Health and Nutrition Examination Survey
Depression and C-reactive protein in US adults - Data from the Third National Health and Nutrition Examination Survey
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DOI：
10.1001/archinte.164.9.1010
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发表时间：
2004-05-10
影响因子：
--
通讯作者：
Erlinger, TP
中科院分区：
文献类型：
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作者：
Ford, DE;Erlinger, TP
背景：抑郁症可能增加心血管疾病风险的生物学机制尚不清楚。炎症可能是动脉粥样硬化性心血管疾病发展的关键因素。我们的目标是在具有国家代表性的队列中确定重度抑郁症与C-反应蛋白(C-反应蛋白)水平升高的相关性。方法：我们从第三次国家健康与营养调查(NHANES III)中估计了6914名非住院男性和女性(年龄18-39岁)中与抑郁症相关的CRP水平升高(>；0.21 mg/mL)的几率。结果：终生重度抑郁症的患病率男性为5.7%，女性为11.7%。C反应蛋白水平升高的男性患病率为13.7%，女性为27.3%。有重度抑郁症病史与CRP水平升高有关(优势比[OR]，1.64；95%可信区间[CI]，1.20-2.24)。抑郁症和C反应蛋白之间的关联在男性中比在女性中强得多。结果根据年龄、非裔美国人种族、体重指数、总胆固醇、对数甘油三酯、糖尿病、收缩压、吸烟状况、酒精使用、女性雌激素使用、阿司匹林使用、布洛芬使用和自我报告的健康状况进行了调整。与无抑郁史的男性相比，最近(1年内)抑郁发作(调整后OR，3.00；95%CI，1.39-6.48)和复发(调整后OR，3.55；95%CI，1.55-8.14)抑郁发作的男性的CRP水平较高。结论：重度抑郁症与男性中CRP水平升高密切相关，有助于解释男性抑郁症相关心血管疾病风险增加的原因。
Background: The biological mechanisms by which depression might increase risk of cardiovascular disease are not clear. Inflammation may be a key element in the development of atherosclerotic cardiovascular disease. Our objective was to determine the association between major depression and elevated C-reactive protein (CRP) level in a nationally representative cohort.Methods: We estimated the odds of elevated CRP level (>0.21 mg/mL) associated with depression in 6914 non-institutionalized men and women (age, 18-39 years) from the Third National Health and Nutrition Examination Survey (NHANES III).Results: The prevalence of lifetime major depression was 5.7% for men and 11.7% for women. The prevalence of elevated CRP level was 13.7% for men and 27.3% for women. A history of major depression was associated with elevated CRP level (odds ratio [OR], 1.64; 95% confidence interval [CI], 1.20-2.24). The association between depression and CRP was much stronger among men than among women. Results were adjusted for age, African American race, body mass index, total cholesterol, log triglycerides, diabetes, systolic blood pressure, smoking status, alcohol use, estrogen use in women, aspirin use, ibuprofen use, and self-reported health status. Compared with men without a history of depression, CRP levels were higher among men who had a more recent (within 1 year) episode of depression (adjusted OR, 3.00; 95% CI, 1.39-6.48) and who had recurrent ( greater than or equal to2 episodes) depression (adjusted OR, 3.55; 95% CI, 1.55-8.14).Conclusion: Major depression is strongly associated with increased levels of CRP among men and could help explain the increased risk of cardiovascular disease associated with depression in men.