RECEPTOR-BINDING RADIOTRACERS FOR THE ANGIOTENSIN-II RECEPTOR - RADIOIODINATED [SAR(1),ILE(8)]ANGIOTENSIN-II
RECEPTOR-BINDING RADIOTRACERS FOR THE ANGIOTENSIN-II RECEPTOR - RADIOIODINATED [SAR(1),ILE(8)]ANGIOTENSIN-II
复制标题
DOI：
10.1016/0969-8051(94)90024-8
复制
发表时间：
1994-05-01
影响因子：
3.1
通讯作者：
BURNS, HD
中科院分区：
文献类型：
--
作者：
GIBSON, RE;BEAUCHAMP, HT;BURNS, HD
使用放射性碘化肽拮抗剂[I-125][Sar（1），Ile（8）]血管紧张素II评价血管紧张素II受体成像的潜力。放射性配体在大鼠的几种组织（肾脏、肾上腺和肝脏）中提供受体介导的信号。3% ID/g肾皮质的受体介导信号应足以允许成像，至少通过SPECT。放射性示踪剂对受体浓度的降低敏感，可用于确定血管紧张素II受体配体的体内剂量占用曲线。在大鼠肾脏和恒河猴肝脏中获得了[I-123][Sar（1），Ile（8）]血管紧张素II的受体介导图像。
The potential for imaging the angiotensin II receptor was evaluated using the radioiodinated peptide antagonist [I-125][Sar(1),Ile(8)]angiotensin II. The radioligand provides a receptor-mediated signal in several tissues in rat (kidneys, adrenal and liver). The receptor-mediated signal of 3% ID/g kidney cortex should be sufficient to permit imaging, at least via SPECT. The radiotracer is sensitive to reductions in receptor concentration and can be used to define in viva dose-occupancy curves of angiotensin II receptor ligands. Receptor-mediated images of [I-123][Sar(1),Ile(8)]angiotensin II were obtained in the rat kidney and Rhesus monkey liver.