Synthetic hydroxyapatite in pharmaceutical applications
Synthetic hydroxyapatite in pharmaceutical applications
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DOI：
10.1016/j.ceramint.2015.10.048
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发表时间：
2016-02-01
影响因子：
5.2
通讯作者：
Jurkitewicz, Maria
中科院分区：
文献类型：
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作者：
Kolmas, Joanna;Krukowski, Sylwester;Jurkitewicz, Maria
合成羟基磷灰石在种植学、口腔医学和再生医学中起着关键作用。由于其无毒和与骨和矿化牙组织的生物相容性，它已被用作骨替代品。多孔颗粒和支架可以由纳米晶羟基磷灰石制成，并且它具有高负载能力，这意味着它可以在制药科学中用作药物载体或药物控释系统。本研究的目的是介绍目前合成羟基磷灰石作为骨组织疾病（多功能植入物）局部治疗药物和难溶性药物（包括生物利用度有限的药物）载体的研究趋势。(C)2015 Elsevier Ltd和Techna Group S.r.l. All rights reserved.
Synthetic hydroxyapatite plays a key role in implantology, stomatology, and regenerative medicine. Thanks to its non-toxicity and biocompatibility with bone and mineralised dental tissues, it has found application as a bone substitute. The fact that porous granules and scaffolds can be made out of nanocrystalline hydroxyapatite, and that it has a high loading capacity, means that it can be used in pharmaceutical science as a carrier for drugs or a system for controlled drug release. The aim of this study is to present current trends in research on synthetic hydroxyapatite as a carrier for drugs used in the local treatment of bone tissue disorders (multifunction implants) and poorly soluble drugs, including those with limited bioavailability. (C) 2015 Elsevier Ltd and Techna Group S.r.l. All rights reserved.