Combining the HYM (Healthy Young Men's) Cohort Study and the TRUTH (A Trans Youth of Color Study): Protocol for an Expanded Mixed Methods Study Renewal.
Combining the HYM (Healthy Young Men's) Cohort Study and the TRUTH (A Trans Youth of Color Study): Protocol for an Expanded Mixed Methods Study Renewal.
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DOI：
10.2196/39232
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发表时间：
2022-11-03
影响因子：
1.7
通讯作者：
Kipke, Michele D.
中科院分区：
文献类型：
--
作者：
Azucar, Danny;Rusow, Joshua A.;Slay, Lindsay;Taiwo, Mariam;Rodriguez, Aracely;Johnson, Ali;Calvetti, Sam;Wright, Deja;Wu, Su;Bray, Bethany;Goldbach, Jeremy T.;Kipke, Michele D.
关键词：
在我们进入艾滋病流行的第五个十年之际，卫生研究人员和艾滋病活动家反思了已经取得的进展以及继续为高危人群开展预防工作的重要性。随着艾滋病毒感染率在各社区继续波动，出现了一种趋势，即新的艾滋病毒感染越来越集中于30岁以下的人，来自边缘化种族和族裔群体，以及性或性别少数群体，并产生级联效应。在本文中，我们讨论了健康青年男性（HYM）队列研究的更新，并增加了一个小组-真理：一个跨性别的青年颜色的研究。我们重新研究的总体目标是为新的干预策略提供信息;了解与护理的联系;并检查随着时间的推移与少数民族相关的压力和交叉身份及其与药物使用，心理健康和艾滋病毒风险的关系的变化。这项研究的结果将有助于为制定新的干预措施提供信息，这些干预措施旨在使非洲裔美国人和黑人和拉丁美洲男男性行为者（YMSM）以及变性人和性别少数青年参与艾滋病毒预防和护理连续体，并通过解决与少数群体有关的压力和交叉污名的途径来降低风险。正在进行纵向研究（基线和随访评估，每6个月一次，共8波数据收集），其中包括HYM队列研究最后一次迭代的重新知情同意队列。本研究方案包括自我报告调查、收集尿液以评估近期使用非法药物的情况，以及收集血液、直肠和咽拭子以检测当前的性传播感染和HIV感染。还采集了额外的血液和血浆样本（10 mL，4等份和1个颗粒），并储存在HYM队列研究生物储存库中，用于未来研究。该混合方法研究设计包括在基线和每6个月收集定量、定性和生物学指标（即，HIV+受试者的药物使用、性传播感染和HIV检测以及抗逆转录病毒治疗依从性）的三角分析。截至2022年2月，过去4年HYM队列研究和TRUTH：有色人种跨性别青年研究队列的参与者已重新获得同意，并被纳入纵向数据收集的更新期，预计从2020年夏季至2025年夏季。招募工作正在进行中，以达到我们的YMSM和跨性别少数民族青年的目标招生目标。这项研究的结果正在用于为新的循证艾滋病毒预防干预措施的制定和现有循证艾滋病毒预防干预措施的调整提供信息，旨在让跨性别者和性别少数青年以及YMSM群体参与艾滋病毒预防和护理的连续性。DERR1-10.2196/39232
As we enter the fifth decade of the AIDS epidemic, health researchers and AIDS activists reflect both on the progress that has been made and the importance of continued prevention efforts for those most at risk. As HIV infection rates continue to fluctuate across communities, a trend has emerged with new HIV infections becoming increasingly concentrated—with cascading effects—among people aged <30 years, from marginalized racial and ethnic groups, and who are sexual or gender minorities. In this paper, we discuss the renewal of the Healthy Young Men’s (HYM) Cohort Study and the addition of a subcohort—TRUTH: A Transgender Youth of Color Study. The overarching aim of our renewed study was to inform new intervention strategies; understand linkage to care; and examine changes over time with respect to minority-related stress and intersectional identities and their relationship with substance use, mental health, and HIV risk. Findings from this study will help to inform the development of new interventions designed to engage African American and Black and Latino young men who have sex with men (YMSM) and transgender and gender minority youth in the HIV prevention and care continua and to reduce risk by addressing pathways of minority-related stress and intersectional stigma. Longitudinal study (baseline and follow-up assessments every 6 months for a total of 8 waves of data collection) is ongoing with reconsented cohort from the last iteration of HYM Cohort Study. This study protocol includes self-report survey, collection of urine to assess recent use of illicit drugs, and collection of blood and rectal and throat swabs to test for current sexually transmitted infection and HIV infection. An additional sample of blood and plasma (10 mL for 4 aliquots and 1 pellet) is also collected and stored in the HYM Cohort Study biorepository for future studies. This mixed methods study design includes collection of triangulated analysis of quantitative, qualitative, and biological measures (ie, drug use, sexually transmitted infection and HIV testing, and adherence to antiretroviral therapy among participants who are HIV+) at baseline and every 6 months. As of February 2022, participants from the past 4 years of the HYM Cohort Study and TRUTH: A Transgender Youth of Color Study Cohort have been reconsented and enrolled into the renewal period of longitudinal data collection, which is projected from summer of 2020 until summer of 2025. Recruitment is ongoing to reach our target enrollment goal of YMSM and transgender minority youth. The findings from this study are being used to inform the development of new, and adaptation of existing, evidence-based HIV prevention interventions designed to engage populations of transgender and gender minority youth and YMSM in the HIV prevention and care continua. DERR1-10.2196/39232
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