Experimental Pilot Study of a Novel Endobronchial Drug Delivery Catheter.
Experimental Pilot Study of a Novel Endobronchial Drug Delivery Catheter.
复制标题
新型支气管内药物输送导管的实验性试点研究。
DOI：
10.1097/lbr.0000000000000209
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发表时间：
2015
影响因子：
3.3
通讯作者：
Ernst,Armin
中科院分区：
文献类型：
--
作者：
Tsukada,Hisashi;Seward,KirkP;Rafeq,Samaan;Kocher,Olivier;Ernst,Armin
背景：通过柔性支气管镜通道引入支气管内输注导管之前尚未描述。本研究的目的是评估一种新的device.Methods的技术可行性：四个猪模型进行支气管镜与输液导管。在第一个实验中，将亚甲蓝以0.1、0.3或1.0 mL的体积注射到2只动物的气道中。在手术后1小时处死一只动物，在手术后24小时处死另一只动物，目视评估总染料扩散。在第二个实验中，将80%无菌生理盐水和20%造影剂的混合物以0.3、1.0和3.0 mL的体积注射到2只动物的气道中。一只动物在第7天处死，另一只在第20天处死。根据支气管损伤评分系统进行组织学评价。结果：无围手术期发病率。在第一项实验中，输注体积为0.1、0.3和1.0 mL时，染料分别围绕输注部位周长的67%± 29%、55%± 17%和80%±20%，纵向分布分别为4.0±1.7、8.1±4.1和18.0±3.0 mm。在第二个实验中，输注0.3至3.0 mL导致轻度损伤，炎症，出血/纤维蛋白/血栓在7和20天后surgery.Conclusions：支气管内输注染料和造影剂的支气管内药物输送导管显示，媒体传播的剂量依赖性的方式宏观和组织学。将需要进一步的调查，以评估导管作为一种新的工具，局部药物输送到气道。
Background:An endobronchial infusion catheter introduced through a flexible bronchoscope channel has not been previously described. The aim of this study was to evaluate the technical feasibility of a new device.Methods:Four porcine models underwent bronchoscopy with the infusion catheter. In the first experiment, methylene blue was injected into airway in volumes of 0.1, 0.3, or 1.0 mL into 2 animals. One animal was killed at 1 hour and the other at 24 hours after the procedure and gross dye diffusion was visually assessed. In the second experiment, a mixture of 80% sterile normal saline and 20% contrast media was injected into the airway in volumes of 0.3, 1.0, and 3.0 mL into 2 animals. One animal was killed at 7 days and the other at 20 days. Histologic evaluations were performed according to a bronchial damage scoring system.Results:There was no perioperative morbidity. In the first experiment, infusion volumes of 0.1, 0.3, and 1.0 mL resulted in dye surrounding 67%±29%, 55%±17%, and 80%±20% of the infusion-site circumference, and longitudinal distribution of 4.0±1.7, 8.1±4.1, and 18.0±3.0 mm each, respectively. In the second experiment, infusion of 0.3 to 3.0 mL resulted in mild injury, inflammation, and hemorrhage/fibrin/thrombus at 7 and 20 days after surgery.Conclusions:Endobronchial infusion of dye and contrast media by the endobronchial drug delivery catheter showed that the media spread in a dose-dependent manner macroscopically and histologically. Further investigation will be required to assess the catheter as a new tool for localized drug delivery into the airway.