Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis.
Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis.
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DOI：
10.1126/scisignal.2003669
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发表时间：
2013-02-26
影响因子：
7.3
通讯作者：
Lapinski PE
中科院分区：
文献类型：
--
作者：
King PD;Lubeck BA;Lapinski PE
在受体信号转导过程中，小的三磷酸鸟苷结合蛋白Ras的失活由Ras鸟苷三磷酸酶（GTdR）激活蛋白（RasGAP）介导。已经确定了10种不同的RasGAP，并且具有重叠的组织分布模式。然而，遗传分析揭示了关键的非冗余功能，每个RasGAP在组织内稳态和调节疾病的过程中，在小鼠和man.here，我们讨论的进展，了解RasGAP在维护组织完整性的作用。
Inactivation of the small guanosine triphosphate–binding protein Ras during receptor signal transduction is mediated by Ras guanosine triphosphatase (GTPase)–activating proteins (RasGAPs). Ten different RasGAPs have been identified and have overlapping patterns of tissue distribution. However, genetic analyses are revealing critical nonredundant functions for each RasGAP in tissue homeostasis and as regulators of disease processes in mouse and man. Here, we discuss advances in understanding the role of RasGAPs in the maintenance of tissue integrity.