Prenatal diagnosis by DNA polymorphism analysis of complete mole with coexisting twin.
Prenatal diagnosis by DNA polymorphism analysis of complete mole with coexisting twin.
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完全性葡萄胎伴双胞胎的DNA多态性分析产前诊断
DOI：
10.1067/mob.2003.151
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发表时间：
2003
影响因子：
9.8
通讯作者：
A. Cartin
中科院分区：
文献类型：
--
作者：
J. Wax;M. Pinette;R. Chard;J. Blackstone;Do;A. Cartin
通过 DNA 多态性分析，部分性葡萄胎与分娩后并存的正常双胞胎的完全性葡萄胎有区别。我们的患者在 12.3 周时对有磨牙的胎盘和共存的胎儿进行了绒毛膜绒毛取样。母体等位基因缺失证实了双雄遗传性完全性葡萄胎。完全性葡萄胎的产前 DNA 诊断是可能的并且在临床上有用。
Partial mole is distinguishable from complete mole with coexisting normal twin after delivery by DNA polymorphysm analysis. Our patient had chorionic villus sampling of a molar-appearing placenta with coexisting fetus at 12.3 weeks. Absent maternal alleles confirmed a diandrogenetic complete mole. Prenatal DNA diagnosis of complete mole is possible and clinically useful.