Differential neural responses evoked by orthonasal versus retronasal odorant perception in humans
Differential neural responses evoked by orthonasal versus retronasal odorant perception in humans
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DOI：
10.1016/j.neuron.2005.07.022
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发表时间：
2005-08-18
期刊：
影响因子：
16.2
通讯作者：
Hummel, T
中科院分区：
文献类型：
--
作者：
Small, DM;Gerber, JC;Hummel, T
通过口腔（后鼻）感知到的气味是指口腔，而通过鼻子（正鼻）感知到的气味是指外部世界。我们通过正鼻和后鼻途径释放汽化的气味剂，并用功能磁共振成像测量大脑反应。后鼻和正鼻给药的比较在中央沟底部的口腔区域产生了优先活动，可能反映了嗅觉转介到口腔，与后鼻嗅觉有关。不同的递送途径在脑岛/盖层、丘脑、海马体、杏仁核和鼻后bbb的尾侧眶额皮质中产生不同的激活，在鼻后>的眶额皮质中产生不同的激活，在巧克力反应中产生不同的激活，但在薰衣草、丁醇或法尼醇反应中没有，因此可以推断出递送途径和气味的相互作用。这些发现表明，不同的神经招募取决于气味管理的途径，并表明其效果受到气味是否代表食物的影响。
Odors perceived through the mouth (retronasally) as flavor are referred to the oral cavity, whereas odors perceived through the nose (orthonasally) are referred to the external world. We delivered vaporized odorants via the orthonasal and retronasal routes and measured brain response with fMRI. Comparison of retronasal versus orthonasal delivery produced preferential activity in the mouth area at the base of the central sulcus, possibly reflecting olfactory referral to the mouth, associated with retronasal olfaction. Routes of delivery produced differential activation in the insula/operculum, thalamus, hippocampus, amygdala, and caudolateral orbitofrontal cortex in orthonasal > retronasal and in the perigenual cingulate and medial orbitofrontal cortex in retronasal > orthonasal in response to chocolate, but not lavender, butanol, or farnesol, so that an interaction of route and odorant may be inferred. These findings demonstrate differential neural recruitment depending upon the route of odorant administration and suggest that its effect is influenced by whether an odorant represents a food.