Brk regulates wing disc growth in part via repression of Myc expression
Brk regulates wing disc growth in part via repression of Myc expression
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DOI：
10.1038/embor.2013.1
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发表时间：
2013-03-01
期刊：
影响因子：
7.7
通讯作者：
Teleman, Aurelio A.
中科院分区：
文献类型：
--
作者：
Doumpas, Nikolaos;Ruiz-Romero, Marina;Teleman, Aurelio A.
调节组织大小的分子机制是发育生物学中未解决的难题。Dpp是控制果蝇翅膀生长的一条信号通路。DPP通过抑制转录因子Brk促进生长。然而，控制细胞生长和增殖的Brk的转录靶点尚未完全阐明。我们在这里报告了一个全基因组的内源性Brk的ChIP-Seq从翼成虫盘。我们确定了生长调节剂Myc作为Brk的靶点，并表明Myc和miRNA bantam的抑制解释了Brk引起的生长抑制的显著部分。这项工作揭示了Dpp信号控制组织生长的效应机制。
The molecular mechanisms regulating tissue size represent an unsolved puzzle in developmental biology. One signalling pathway controlling growth of the Drosophila wing is Dpp. Dpp promotes growth by repression of the transcription factor Brk. The transcriptional targets of Brk that control cell growth and proliferation, however, are not yet fully elucidated. We report here a genome-wide ChIP-Seq of endogenous Brk from wing imaginal discs. We identify the growth regulator Myc as a target of Brk and show that repression of Myc and of the miRNA bantam explains a significant fraction of the growth inhibition caused by Brk. This work sheds light on the effector mechanisms by which Dpp signalling controls tissue growth.