A proposed role for adenosine in the regulation of renal hemodynamics and renin release.
A proposed role for adenosine in the regulation of renal hemodynamics and renin release.
复制标题
腺苷在肾血流动力学和肾素释放调节中的拟议作用。
DOI：
10.1152/ajprenal.1982.242.5.f423
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Thompson,CI
中科院分区：
文献类型：
--
作者：
Spielman,WS;Thompson,CI
腺苷由肾组织产生，对肾血流量及其分布、肾小球滤过率（GFR）和肾素分泌有显著影响。肾内灌注腺苷降低GFR主要是通过降低肾小球静水压力，其作用是增加传入小动脉阻力并可能降低传出小动脉阻力。由于腺苷引起的GFR下降伴随着器官总血流量的微小变化或增加。腺苷输注时，局部肾血流被重新分配，总血流的更大比例流向髓旁皮质。肾内腺苷显著减少水和钠的排泄，其比例大于其对GFR的影响，提示可能直接作用于肾小管。肾内腺苷对肾素释放也产生快速而明显的抑制作用，这种抑制作用似乎独立于其血流动力学或肾小管效应。本文考虑了以腺苷为介质控制肾小球滤过率和肾素释放的代谢假说，并讨论了腺苷在肾内调节肾功能中的作用标准。
Adenosine is produced by renal tissue and has potent effects on renal blood flow and its distribution, glomerular filtration rate (GFR), and the secretion of renin. Intrarenal infusion of adenosine decreases GFR primarily by decreasing glomerular hydrostatic pressure through its effects in increasing afferent arteriolar resistance and possibly decreasing efferent arteriolar resistance. The fall in GFR due to adenosine is accompanied by little change or an increase in total organ blood flow. Regional renal blood flow during adenosine infusion is redistributed, with a greater percentage of total flow going to the juxtamedullary cortex. Intrarenal adenosine produces marked decreases in water and sodium excretion that are proportionally greater than its effect on GFR, suggesting a possible direct tubular action. Intrarenal adenosine also produces a rapid and pronounced inhibition of renin release that appears to be independent of its hemodynamic or tubular effects. A metabolic hypothesis for the control of glomerular filtration rate and renin release with adenosine acting as a mediator is considered, and criteria for establishing an intrarenal role for adenosine in the regulation of renal function are discussed.