Increased expression of N-myc downstream-regulated gene 1 (NDRG1) in placentas from pregnancies complicated by intrauterine growth restriction or preeclampsia
Increased expression of N-myc downstream-regulated gene 1 (NDRG1) in placentas from pregnancies complicated by intrauterine growth restriction or preeclampsia
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DOI：
10.1016/j.ajog.2006.08.029
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发表时间：
2007-01-01
影响因子：
9.8
通讯作者：
Roh, Cheong-Rae
中科院分区：
文献类型：
--
作者：
Choi, Suk-Joo;Oh, Soo-young;Roh, Cheong-Rae
N-myc下游调节基因1是最近鉴定的基因产物，已知其在调节滋养层分化和对损伤的反应中具有作用。通过使用免疫染色，Western免疫印迹和实时定量聚合酶链反应，我们发现，N-myc下游调节基因1的表达上调，从妊娠并发宫内生长受限或重度先兆子痫的胎盘。
N-myc downstream-regulated gene 1 is a recently identified gene product that is known to have a role in regulation of trophoblast differentiation and response to injury. By using immuno-staining, Western immunoblotting, and real-time quantitative polymerase chain reaction, we found that the expression of N-myc downstream-regulated gene 1 is upregulated in placentas from pregnancies complicated by intrauterine growth restriction or severe preeclampsia.