The Role of Autophagy in the Pathogenesis of Ischemic Stroke.
The Role of Autophagy in the Pathogenesis of Ischemic Stroke.
复制标题
自噬在缺血性中风发病机制中的作用
DOI：
10.2174/1570159x18666200729101913
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发表时间：
2021
影响因子：
5.3
通讯作者：
Chen C
中科院分区：
文献类型：
--
作者：
Shi Q;Cheng Q;Chen C
自噬是一个严格调控的过程，可降解和回收长寿命或错误折叠的蛋白质和受损的细胞器，以维持细胞的能量和功能稳态。脑缺血引起的氧和糖供应不足，导致AMP/ATP比值升高，从而激活AMPK通路，启动自噬过程。越来越多的证据表明，自噬作为一把双刃剑参与了缺血性中风的发病机制。然而，自噬在缺血性中风发病机制中的确切作用尚存在争议且尚未阐明。在这篇综述中，阐述了生理条件和缺血性中风中的自噬途径。重点还讨论了自噬在脑缺血中的双刃剑效应及其潜在机制。此外，还回顾了针对自噬途径的缺血性中风的潜在治疗策略。
Autophagy is a strictly regulated process that degrades and recycles long-lived or misfolded proteins and damaged organelles for the maintenance of energy and function homeostasis of cells. Insufficient oxygen and glucose supply caused by cerebral ischemia lead to a higher ratio of AMP/ATP, which will activate the AMPK pathway to initiate the process of autophagy. Accumulating evidence shows that autophagy participates in the pathogenesis of ischemic stroke as a double-edged sword. However, the exact role of autophagy in the pathogenesis of ischemic stroke is controversial and yet to be elucidated. In this review, the autophagy pathway, both in physiological conditions and in ischemic stroke, is expounded. The focus was also on discussing the double-edged sword effect of autophagy in brain ischemia and its underlying mechanisms. In addition, potential therapeutic strategies for ischemic stroke targeting autophagy pathway were also reviewed.