Trace metal concentrations in hair and nails from Alzheimer's disease patients: Relations with clinical severity
Trace metal concentrations in hair and nails from Alzheimer's disease patients: Relations with clinical severity
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DOI：
10.1016/j.jtemb.2016.09.002
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发表时间：
2017-01-01
影响因子：
3.5
通讯作者：
Saraymen, Burak
中科院分区：
文献类型：
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作者：
Koseoglu, Emel;Koseoglu, Rahmi;Saraymen, Burak
背景和目的：金属，特别是过渡金属，在阿尔茨海默病的发病机制中似乎很重要。本研究旨在从临床严重程度方面确定微量金属元素与阿尔茨海默病发病机制和/或病程的关系。方法：采用电感耦合等离子体质谱法测定62例阿尔茨海默病不同临床分期患者（轻度21例、中度20例、重度21例）和60例健康对照者的头发和指甲微量金属含量。对各研究组、临床分期、病程、年龄进行统计学比较。结果：患者组与对照组在锰、铁、铜、镉、汞含量上有显著性差异(p
Background and objectives: Metals, especially transition metals, seem to be important in the pathogenesis of Alzheimer disease. This study aims to determine the relationship of trace metal elements to the pathogenesis and/or course of Alzheimer Disease in terms of clinical severity.Methods: The hair and nail trace metal levels of 62 Alzheimer Disease patients at different clinical stages (21 mild, 20 moderate, 21 severe) and 60 healthy control subjects were measured by using inductively coupled plasma-mass spectrometry. The statistical comparisons were performed with regards to the study groups, clinical stages, disease duration and age.Results: The patient and control groups were significantly different from each other in regards to Mn, Fe, Cu, Cd, Hg (p