Efficient Use of Photons in Photoredox/Enamine Dual Catalysis with a Peptide-Bridged Flavin-Amine Hybrid
Efficient Use of Photons in Photoredox/Enamine Dual Catalysis with a Peptide-Bridged Flavin-Amine Hybrid
复制标题
通过肽桥黄素-胺杂化物在光氧化还原/烯胺双重催化中有效利用光子
DOI：
10.1021/acs.orglett.9b02567
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发表时间：
2019
期刊：
影响因子：
5.2
通讯作者：
Yasushi Imada
中科院分区：
文献类型：
--
作者：
Takuma Tagami;Yukihiro Arakawa;Keiji Minagawa;Yasushi Imada
异咯嗪（黄素）环系统和仲胺已通过短肽连接体整合，目的是在光氧化还原/烯胺双重催化中尽可能有效地使用光子。我们在此报道了一种肽桥黄素-胺杂化物，可以在弱蓝光照射下用TEMPO催化醛的α-氧胺化，从而实现极高的反应量子产率（Φ = 0.80）。
An isoalloxazine (flavin) ring system and a secondary amine have been integrated through a short peptide linker with the aim of using photons as efficiently as possible in photoredox/enamine dual catalysis. We herein report a peptide-bridged flavin–amine hybrid that can catalyze α-oxyamination of aldehydes with TEMPO under weak blue light irradiation to achieve an extremely high quantum yield of reaction (Φ = 0.80).