Graft-versus-host disease and survival after cord blood transplantation for acute leukemia: a comparison of Japanese versus White populations.
Graft-versus-host disease and survival after cord blood transplantation for acute leukemia: a comparison of Japanese versus White populations.
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移植物抗宿主病和脐带血移植治疗急性白血病后的存活率：日本人和白人的比较。
DOI：
10.1016/j.bbmt.2014.01.020
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发表时间：
2014-05
影响因子：
4.3
通讯作者：
Eapen, Mary
中科院分区：
文献类型：
--
作者：
Kuwatsuka, Yachiyo;Atsuta, Yoshiko;Horowitz, Mary M.;Inagaki, Jiro;Kanda, Junya;Kato, Koji;Koh, Katsuyoshi;Zhang, Mei-Jie;Eapen, Mary
早期的一份报告发现，在进行 HLA 匹配的兄弟姐妹移植后，白人儿童患急性和慢性移植物抗宿主病 (GVHD) 的风险高于日本儿童。当前的分析探讨了种族差异是否与无关脐带血移植后的 GVHD 风险相关。其中包括日本血统患者 (n = 257) 和白人患者 (n = 260；260 名患者中的 168 名接受了抗胸腺细胞球蛋白 [ATG])。 2000年至2009年间在美国或日本进行了移植；患者年龄为 16 岁或以下，患有急性白血病，已完全缓解，并接受了清髓性预处理方案。接受 ATG 的日本人和白人的中位年龄为 5 岁，而未接受 ATG 的白人的中位年龄为 8 岁。在所有组中，大多数移植物在 1 或 2 个 HLA 基因座处不匹配。多变量分析发现日本人和白人之间急性 GVHD 的风险没有差异。然而，与日本人相比，未接受 ATG 的白人的慢性 GVHD 较高（风险比为 2.16；P < .001），接受 ATG 的白人与日本人相比，治疗相关死亡率更高（相对风险为 1.81；P = .01）。然而，三组之间的总生存率没有显着差异。
An earlier report identified higher risks of acute and chronic graft-versus-host disease (GVHD) in White children compared with the Japanese after HLA-matched sibling transplantations. The current analysis explored whether racial differences are associated with GVHD risks after unrelated umbilical cord blood transplantation. Included are patients of Japanese descent (n = 257) and Whites (n = 260; 168 of 260 received antithymocyte globulin [ATG]). Transplants were performed in the United States or Japan between 2000 and 2009; patients were aged 16 years or younger, had acute leukemia, were in complete remission, and received a myeloablative conditioning regimen. The median ages of the Japanese and Whites who received ATG were younger at 5 years compared with 8 years for Whites who did not receive ATG. In all groups most transplants were mismatched at 1 or 2 HLA loci. Multivariate analysis found no differences in risks of acute GVHD between the Japanese and Whites. However, chronic GVHD was higher in Whites who did not receive ATG compared with the Japanese (hazard ratio, 2.16; P < .001), and treatment-related mortality was higher in Whites who received ATG compared with the Japanese (relative risk, 1.81; P = .01). Nevertheless, there were no significant differences in overall survival between the 3 groups.
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在HLA A，B，C和DRB1匹配的供体 - 辅助HLA对白血病和骨髓增生综合征的脐带血液移植后结果的影响：回顾性分析。
DOI：
10.1016/s1470-2045(11)70260-1
发表时间：
2011-12
期刊：
The Lancet. Oncology
影响因子：
--
作者：
Eapen M;Klein JP;Sanz GF;Spellman S;Ruggeri A;Anasetti C;Brown M;Champlin RE;Garcia-Lopez J;Hattersely G;Koegler G;Laughlin MJ;Michel G;Nabhan SK;Smith FO;Horowitz MM;Gluckman E;Rocha V;Eurocord-European Group for Blood and Marrow Transplantation;Netcord;Center for International Blood and Marrow Transplant Research
通讯作者：
Center for International Blood and Marrow Transplant Research
影响因子：
158.5
作者：
Laughlin, MJ;Eapen, M;Horowitz, MM
通讯作者：
Horowitz, MM
影响因子：
20.3
作者：
Narimatsu, Hiroto;Miyakoshi, Shigesaburo;Kato, Shunichi
通讯作者：
Kato, Shunichi
影响因子：
20.3
作者：
Takahashi, S;Iseki, T;Asano, S
通讯作者：
Asano, S
影响因子：
20.3
作者：
Eapen, Mary;Klein, John P.;Rocha, Vanderson
通讯作者：
Rocha, Vanderson