Insulin-like growth factors I and II in evaluation of growth retardation.
Insulin-like growth factors I and II in evaluation of growth retardation.
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胰岛素样生长因子 I 和 II 用于评估生长迟缓。
DOI：
10.1016/s0022-3476(86)80112-3
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Hintz,RL
中科院分区：
文献类型：
--
作者：
Rosenfeld,RG;Wilson,DM;Lee,PD;Hintz,RL
本文对68例生长激素（GH）缺乏儿童（刺激血清GH水平<7 ng/ml）、44例正常矮个子儿童和197例正常身高儿童的血浆样本进行了生长激素肽、胰岛素样生长因子(IGF)-I和-II的特异性放射免疫测定。18%的gh缺陷儿童的IGF-I水平在正常年龄范围内，而32%的正常矮个子儿童的IGF-I水平较低。在52%的gh缺陷儿童中发现IGF-II水平低，但在35%的正常矮个子儿童中也发现IGF-II水平低。然而，只有4%的gh缺乏儿童的血浆IGF-I和IGF-II水平正常。此外，只有0.5%的正常儿童和11%的正常矮个子儿童的血浆IGF-I和IGF-II水平较低。我们的结论是，血浆中IGF-I或IGF-II水平在gh缺陷儿童和正常矮个子儿童中重叠，但放射免疫测定的结合可以更好地区分正常、正常矮个子和gh缺陷儿童。
Plasma samples from 68 growth hormone (GH)-deficient children (provocative serum GH level <7 ng/ml), 44 normal short children, and 197 children with normal height were asseyed by specific radioimmunoassays for the somatomedin peptides, insulin-like growth factors (IGF)-I and -II. Eighteen percent of the GH-deficient children had IGF-I levels within the normal range for age, whereas 32% of normal short children had low IGF-I levels. Low IGF-II levels were found in 52% of GH-deficient children, but also in 35% of normal short children. However, only 4% of GH-deficient children had normal plasma levels of both IGF-I and IGF-II. Furthermore, only 0.5% of normal children and 11% of normal short children had low plasma levels of both IGF-I and IGF-II. We conclude that plasma levels of either IGF-I or IGF-II overlap in GH-deficient and normal short children, but that the combination of radioimmunoassays may permit better discrimination among normal, normal short, and GH-deficient children.