Versatile Nanoporous Organic Polymer Catalyst for the Size-Selective Suzuki–Miyaura Coupling Reaction
Versatile Nanoporous Organic Polymer Catalyst for the Size-Selective Suzuki–Miyaura Coupling Reaction
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DOI：
10.1021/acsanm.2c04393
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发表时间：
2022-12
影响因子：
5.9
通讯作者：
Shengjin Guo;Yifan Wu;Shao-Xiong Lennon Luo;T. Swager
中科院分区：
文献类型：
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作者：
Shengjin Guo;Yifan Wu;Shao-Xiong Lennon Luo;T. Swager
具有限定的纳米孔催化位点的多相催化剂具有高的活性和尺寸选择性。一种可溶液加工的纳米多孔有机聚合物（1-BPy-Pd）催化剂在非均相Suzuki-Miyaura偶联（SMC）反应中显示出高催化性能（TON > 200 K），并可用于制备药物合成中的中间体。与均相催化剂类似物（2，2 ′-BPy）PdCl 2相比，当使用体积较大的底物时，非均相体系提供尺寸依赖的催化活性。此外，催化剂可用于制造简化其使用和回收的催化叶轮。我们发现，该系统也适用于非均相Heck和硝基芳烃还原反应的应用。本文报道的金属结合纳米多孔聚合物代表了尺寸选择性非均相和可回收催化剂的通用平台。
Heterogenous catalysts with confined nanoporous catalytic sites are shown to have high activity and size selectivity. A solution-processable nanoporous organic polymer (1-BPy-Pd) catalyst displays high catalytic performance (TON > 200K) in the heterogeneous Suzuki–Miyaura coupling (SMC) reaction and can be used for the preparation of the intermediates in the synthesis of pharmaceutical agents. In comparison to the homogeneous catalyst analogue (2,2′-BPy)PdCl2, the heterogenous system offers size-dependent catalytic activity when bulkier substrates are used. Furthermore, the catalyst can be used to create catalytic impellers that simplify its use and recovery. We found that this system also works for applications in heterogenous Heck and nitroarenes reduction reactions. The metal-binding nanoporous polymer reported here represents a versatile platform for size-selective heterogeneous and recyclable catalysts.