Effect of Drugs on the Uptake and Release of 3H-Norepinephrine in the Rat Heart
Effect of Drugs on the Uptake and Release of 3H-Norepinephrine in the Rat Heart
复制标题
药物对大鼠心脏3H-去甲肾上腺素摄取和释放的影响
作者：
J. Axelrod;G. Hertting;L. Potter
在给予各种药物后，如精神活性药物（利血平、氯丙嗪、丙咪嗪）、拟交感神经胺（酪胺、安非他明）、可卡因、肾上腺素能阻滞剂（酚苄明）和消肿药物（乙啶），在心脏、脾脏和肾上腺中发现较低浓度的注射3 H-去甲肾上腺素1 -3。这些药物中的大多数还增加了整个小鼠中3 H-去甲肾上腺素的代谢率，推测是通过阻止激素的保护性结合并使其暴露于酶攻击4，5。虽然这些药物有多种作用，但它们可以通过不同的机制产生共同的最终结果。它们可能通过阻断循环中的儿茶酚胺进入储存部位、阻止结合或导致结合的3 H-去甲肾上腺素释放或通过这些方法的组合来降低3 H-去甲肾上腺素的组织水平。
FOLLOWING the administration of a wide variety of drugs such as psychoactive agents (reserpine, chlorpromazine, imipramine), sympathomimetic amines (tyramine, amphetamine), cocaine, adrenergic blocking agents (phenoxybenzamine), and hypotensive drugs (guanethidine) a lower concentration of injected 3H-noradrenaline was found in the heart, spleen and adrenal glands1–3. Most of these drugs also increase the rate of metabolism of 3H-noradrenaline in the whole mouse presumably by preventing the protective binding of the hormone and exposing it to enzymatic attack4,5. Although these drugs have many actions, they could produce a common-end result by different mechanisms. They might lower the tissue levels of 3H-noradrenaline by blocking the entry of the circulating catecholamine into the storage site, preventing the binding or causing the release of the bound 3H-noradrenaline or by a combination of these.