Modulation of brain response to emotional images by alcohol cues in alcohol-dependent patients
Modulation of brain response to emotional images by alcohol cues in alcohol-dependent patients
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DOI：
10.1111/j.1369-1600.2008.00111.x
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发表时间：
2008-09-01
影响因子：
3.4
通讯作者：
Hommer, Daniel W.
中科院分区：
文献类型：
--
作者：
Gilman, Jodi M.;Hommer, Daniel W.
酒精经常被用来调节情绪状态。饮酒者报告说，他们使用酒精既可以增强积极情绪，又可以减少烦躁不安，而酒精依赖患者特别指出，减少消极情绪是饮酒的主要原因。目前的研究表明，酒精暗示可能会减少酗酒者的负面影响。我们使用功能性磁共振成像来检查大脑对组合图像的反应，这些组合图像将负性或正性国际情感图片系统（IAPS）图像与酒精或不含酒精的饮料并置。我们发现，在没有酒精提示的情况下，酗酒者对负面图像的激活程度高于对正面图像的激活程度，对负面图像的激活程度也高于对照组。当 IAPS 图像与酒精提示一起呈现时，酗酒者之间的积极图像和消极图像之间的激活差异减小，并且对照组和酗酒者之间对消极图像的反应差异减小。此外，在中性饮料条件下，焦虑等级显着预测右侧海马旁回的激活，但不能预测酒精提示出现时的激活。总之，酒精线索可能通过在酗酒者中引发条件反应来调节参与情绪刺激处理的皮质网络，但在对照组中则不然，这可能会降低对负面图像的反应。
Alcohol is often used to modulate mood states. Alcohol drinkers report that they use alcohol both to enhance positive affect and to reduce dysphoria, and alcohol-dependent patients specifically state reduction of negative affect as a primary reason for drinking. The current study proposes that alcohol cues may reduce negative affect in alcoholics. We used functional magnetic resonance imaging to examine brain activation in response to combination images that juxtaposed negative or positive International Affective Picture System (IAPS) images with an alcohol or non-alcohol-containing beverage. We found that in the absence of the alcohol cue, alcoholics showed more activation to negative than to positive images and greater activation than controls to negative images. When the IAPS images were presented with the alcohol cue, there was a decreased difference in activation between the positive and negative images among the alcoholics, and a decreased difference in response to the negative images between controls and alcoholics. Additionally, in the neutral-beverage conditions, anxiety ratings significantly predicted activation in the right parahippocampal gyrus but did not predict activation when the alcohol cues were presented. In conclusion, the alcohol cues may have modulated cortical networks involved in the processing of emotional stimuli by eliciting a conditioned response in the alcoholics, but not in the controls, which may have decreased responsiveness to the negative images.