The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease.
The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease.
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DOI：
10.1186/rr177
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发表时间：
2002
影响因子：
5.8
通讯作者：
Strieter RM
中科院分区：
文献类型：
--
作者：
Keane MP;Strieter RM
肺对各种损伤的反应非常一致，但结果不一致，从完全消退和恢复正常到正常结构破坏和进行性纤维化。越来越多的证据表明，弥漫性肺病是由促炎和抗炎机制之间的不平衡引起的，这种持续的不平衡有利于促炎介质，从而决定了慢性弥漫性肺病的发展。这篇综述的重点是影响这种不平衡的介质。
The lung responds to a variety of insults in a remarkably consistent fashion but with inconsistent outcomes that vary from complete resolution and return to normal to the destruction of normal architecture and progressive fibrosis. Increasing evidence indicates that diffuse lung disease results from an imbalance between the pro-inflammatory and anti-inflammatory mechanisms, with a persistent imbalance that favors pro-inflammatory mediators dictating the development of chronic diffuse lung disease. This review focuses on the mediators that influence this imbalance.