Transformational Impact of Nanomedicine: Reconciling Outcome with Promise.
Transformational Impact of Nanomedicine: Reconciling Outcome with Promise.
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DOI：
10.1021/acs.nanolett.0c02738
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发表时间：
2020-08-12
期刊：
影响因子：
10.8
通讯作者：
Nel AE MD/DSc
中科院分区：
文献类型：
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作者：
Nel AE MD/DSc
虽然纳米科学和技术对医学的贡献是有影响的，但一些专家声称对纳米医学没有兑现其承诺感到失望。1在权衡这些观点之前，重要的是要澄清，在纳米技术在医学中的各种应用中，治疗学受到了最多的关注，导致人们认为纳米医学主要集中在使用治疗或成像纳米颗粒来提高治疗效果和通过控制药物生物分布来降低毒性。1虽然无可争议的是，纳米载体有助于改善治疗效果，药代动力学，生物屏障的跨越和安全性，但该领域有望扩展到治疗性纳米颗粒的使用之外。1− 3这是可行的，通过使用固有的纳米材料特性，能够改善目前的诊断，成像和治疗方式。4我们还可以利用在第一波治疗应用开发过程中获得的经验，对免疫治疗、神经病学、心血管和传染病、抗炎和抗衰老应用、再生医学、护肤和整形外科产生重大影响。这些努力依赖于临床医生，监管机构和跨学科工作人员的积极参与，以促进物理化学和生物医学科学之间的合作，将纳米医学作为医疗保健系统的一个组成部分。
While the contributions of nanoscience and technology to medicine have been impactful, some experts claim to be disappointed that nanomedicine did not deliver on its promises. 1 Before weighing in on these opinions, it is important to clarify that among the diverse applications of nanotechnology in medicine, therapeutics have received the most attention, leading to a perception that nanomedicine is mainly focused on using therapeutic or imaging nanoparticles to improve treatment efficacy and toxicity reduction by controlling drug biodistribution. 1 While it is indisputable that nanocarriers have contributed to improvement of treatment efficacy, pharmacokinetics, crossing of biological barriers, and safety, the field is poised to expand beyond the use of therapeutic nanoparticles. 1− 3 This is feasible through the use of intrinsic nanomaterial properties that are capable of improving over current diagnostic, imaging, and therapeutic modalities. 4 We can also use the experience gained during the development of the first wave of therapeutic applications to achieve major impact on immunotherapy, neurology, cardiovascular and infectious diseases, anti-inflammatory and antiaging applications, regenerative medicine, skincare and orthopedics. 1 These efforts depend on the active involvement of clinicians, regulatory agencies, and an interdisciplinary workforce to promote cooperation between physicochemical and biomedical sciences in establishing nanomedicine as an integral component of the healthcare system.
影响因子：
18.3
作者：
Nel, Andre;Xia, Tian;Meng, Huan;Wang, Xiang;Lin, Sijie;Ji, Zhaoxia;Zhang, Haiyuan
通讯作者：
Zhang, Haiyuan