Field Potential Signature of Distinct Multicellular Activity Patterns in the Mouse Hippocampus
Field Potential Signature of Distinct Multicellular Activity Patterns in the Mouse Hippocampus
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DOI：
10.1523/jneurosci.2535-10.2010
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发表时间：
2010-11-17
影响因子：
5.3
通讯作者：
Both, Martin
中科院分区：
文献类型：
--
作者：
Reichinnek, Susanne;Kuensting, Thomas;Both, Martin
认知功能沿着神经元网络中复杂的分布式活动模式，从而形成选定神经元的集合。为了支持记忆过程，这些组件必须以高度可重复的方式稳定和重新激活。啮齿类动物海马为空间记忆形成的网络机制提供了一个很好的研究模型系统。位置编码细胞的集合在与睡眠相关的网络状态中被反复激活，这种状态被称为尖波波纹复合体（SPW-R）。行为研究表明，在任何时候，海马体都有数量有限的不同组件，这些组件暂时稳定下来，以巩固记忆。我们假设相应的场电位（尖波波纹复合体）包含潜在神经元活动模式的特定签名。因此，它们应该落入有限数量的不同波形中。无偏排序算法的应用，以尖锐的波波纹复合物在小鼠海马切片确实揭示了可靠的复发定义的波形，是强大的长期记录期间。单单位放电往往选择性地与某些SPW-R类火灾，并耦合以上的机会水平。因此，不同波形的场SPW-R与以高保真度再现的潜在多细胞活动模式直接相关。不同神经元群的协调活动与宏观电图信号之间的这种直接关系对于人类和行为动物的认知相关生理研究可能是重要的。
Cognitive functions go along with complex patterns of distributed activity in neuronal networks, thereby forming assemblies of selected neurons. To support memory processes, such assemblies have to be stabilized and reactivated in a highly reproducible way. The rodent hippocampus provides a well studied model system for network mechanisms underlying spatial memory formation. Assemblies of place-encoding cells are repeatedly activated during sleep-associated network states called sharp wave-ripple complexes (SPW-Rs). Behavioral studies suggest that at any time the hippocampus harbors a limited number of different assemblies that are transiently stabilized for memory consolidation. We hypothesized that the corresponding field potentials (sharp wave-ripple complexes) contain a specific signature of the underlying neuronal activity patterns. Hence, they should fall into a limited number of different waveforms. Application of unbiased sorting algorithms to sharp wave-ripple complexes in mouse hippocampal slices did indeed reveal the reliable recurrence of defined waveforms that were robust over prolonged recording periods. Single-unit discharges tended to fire selectively with certain SPW-R classes and were coupled above chance level. Thus, field SPW-Rs of different waveforms are directly related to the underlying multicellular activity patterns that recur with high fidelity. This direct relationship between the coordinated activity of distinct groups of neurons and macroscopic electrographic signals may be important for cognition-related physiological studies in humans and behaving animals.