Association of haptoglobin with sodium sensitivity and resistance of blood pressure.
Association of haptoglobin with sodium sensitivity and resistance of blood pressure.
复制标题
触珠蛋白与钠敏感性和血压抵抗力的关联。
DOI：
10.1161/01.hyp.10.4.443
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Christian,JC
中科院分区：
文献类型：
--
作者：
Weinberger,MH;Miller,JZ;Fineberg,NS;Luft,FC;Grim,CE;Christian,JC
本文测定了117例正常血压和85例高血压患者的钠敏感性和血压阻力。方法为快速扩张细胞外液容量，静脉注射生理盐水(2 L，持续4h)，然后每天低钠饮食(10mEq)，利尿剂(速尿，口服120 mg)引起容量收缩。还对遗传标记进行了检测。具有结合珠蛋白1-1表型的高血压患者和血压正常的受试者对钠敏感的可能性均显著高于2-1或2-2表型的受试者(p<0.05)，且2-2表型的受试者更容易发生钠抵抗。第二组人群中，结合珠蛋白1-1表型的成人和儿童都被发现有显着(P<0.05)较高的随意收缩和舒张压。这两项研究独立地证实了结合珠蛋白表型和血压之间的关系，并提出了环境因素(钠)。
Sodium sensitivity and resistance of blood pressure were examined in 117 normotensive and 85 hypertensive subjects by means of a protocol using rapid extracellular fluid volume expansion with intravenously administered saline (2 L over 4 hours) followed by a day of low dietary sodium intake (10 mEq) and volume contraction induced by a diuretic (furosemide, 120 mg orally). Genetic markers were also examined. Both hypertensive and normotensive subjects with haptoglobin 1-1 phenotype were significantly more (p less than 0.05) likely to be sodium-sensitive than were those with 2-1 or 2-2 phenotypes, and subjects with 2-2 phenotypes were more apt to be sodium-resistant. A second population was examined in which both adults and children with haptoglobin 1-1 phenotype were found to have significantly (p less than 0.05) higher casual systolic and diastolic blood pressures. These two studies independently confirm a relationship between haptoglobin phenotypes and blood pressure and suggest an environmental factor (sodium) as well.