An area for vergence eye movement in primate frontal cortex
An area for vergence eye movement in primate frontal cortex
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DOI：
10.1038/35039506
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发表时间：
2000-10-26
期刊：
影响因子：
64.8
通讯作者：
Yoon, K
中科院分区：
文献类型：
--
作者：
Gamlin, PD;Yoon, K
为了观察不同距离的物体，人类依靠聚光眼运动来适当地使眼睛收敛或发散，并依靠眼调节来聚焦物体（1,2）。尽管这些协调的眼球运动（“近距离反应”）很重要，但我们对大脑皮层在它们的控制中所起的作用知之甚少。由于近反应神经元存在于桥状网状核内(3)，其接收额叶皮层额叶视野区域的输入（4-6），并且该皮层区域已知参与跳眼（7-9）和平滑追求眼运动（10-12），我们提出附近区域可能在趋同和眼调节中发挥作用。在这里，我们提供了来自恒河猴的证据，证明位于与眼珠相关的额叶视野区前方的额叶皮层区域参与了视距和眼调节，以及这些眼球运动所需的感觉运动转换。我们得出结论，猕猴的额叶皮层参与控制所有的眼球运动，并建议额叶视野的定义应该扩大到包括这一区域。
To view objects at different distances, humans rely on vergence eye movements to appropriately converge or diverge the eyes and on ocular accommodation to focus the object(1,2). Despite the importance of these coordinated eye movements (the 'near response') very little is known about the role of the cerebral cortex in their control. As near-response neurons exist within the nucleus reticularis tegmenti pontis(3), which receives input from the frontal eye field region of frontal cortex(4-6), and this cortical region is known to be involved in saccadic(7-9) and smooth-pursuit eye movements(10-12), we propose that a nearby region might play a role in vergence and ocular accommodation. Here we provide evidence from rhesus monkeys that a region of frontal cortex located immediately anterior to the saccade-related frontal eye field region is involved in vergence and ocular accommodation, and in the sensorimotor transformations required for these eye movements. We conclude that the macaque frontal cortex is involved in the control of all voluntary eye movements, and suggest that the definition of the frontal eye fields should be expanded to include this region.