Hetero-stereocomplex formation between substituted poly(lactic acid)s with linear and branched side chains, poly(l-2-hydroxybutanoic acid) and poly(d-2-hydroxy-3-methylbutanoic acid)
Hetero-stereocomplex formation between substituted poly(lactic acid)s with linear and branched side chains, poly(l-2-hydroxybutanoic acid) and poly(d-2-hydroxy-3-methylbutanoic acid)
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DOI：
10.1016/j.polymer.2013.12.053
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发表时间：
2014-02
期刊：
影响因子：
4.6
通讯作者：
H. Tsuji;T. Hayakawa
中科院分区：
文献类型：
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作者：
H. Tsuji;T. Hayakawa
差示扫描量热法和广角x射线衍射首次揭示了具有不同化学结构和相反构型的可生物降解、光学活性和等规聚2-羟基烷酸之间形成的杂立体配合物（HTSC），即具有线性侧链（乙基）的l-构型取代聚乳酸（PLA）[聚（l-2-羟基丁酸），P(l-2HB)]和构型取代PLA[聚（d-2-羟基-3-甲基丁酸）]。P(d-2H3MB)]与支链侧链（异丙基）在溶液和从熔体中散装。P(l-2HB)/P(d-2H3MB) HTSC晶的熔融温度为197 ~ 204℃，远高于P（l-2HB）和P（d-2H3MB）均晶（分别为100 ~ 101℃和158 ~ 165℃）。P(l-2HB)/P(d-2H3MB) HTSC晶体的解释距离和晶格尺寸分别大于P(l-2HB)/P（d-2HB）和P(l-2H3MB)/P（d-2H3MB）同相立体配合物的解释距离和晶格尺寸。本研究中报道的具有相反构型的取代聚乳酸的HTSC形成将为制备具有多种物理性质和生物降解性的聚2-羟基烷酸基生物降解材料提供一种通用方法。
Differential scanning calorimetry and wide-angle X-ray diffractometry first revealed the formation of hetero-stereocomplex (HTSC) between biodegradable, optically active, and isotactic poly(2-hydroxyalkanoic acid)s having different chemical structures and opposite configurations, i.e.,l-configured substituted poly(lactic acid) (PLA) [poly(l-2-hydroxybutanoic acid), P(l-2HB)] with linear side chains (ethyl groups) andd-configured substituted PLA [poly(d-2-hydroxy-3-methylbutanoic acid), P(d-2H3MB)] with branched side chains (isopropyl groups) in solution and in bulk from the melt. The melting temperature of P(l-2HB)/P(d-2H3MB) HTSC crystallites was 197–204 °C, which is much higher those of P(l-2HB) and P(d-2H3MB) homo-crystallites (100–101 °C and 158–165 °C, respectively). The interplain distances and crystalline lattice sizes of P(l-2HB)/P(d-2H3MB) HTSC crystallites were respectively larger and smaller than those of P(l-2HB)/P(d-2HB) and P(l-2H3MB)/P(d-2H3MB) homo-stereocomplexes. The HTSC formation of substituted PLA with opposite configurations reported in the present study will provide a versatile way to prepare poly(2-hydroxyalkanoic acid)-based biodegradable materials having a wide variety of physical properties and biodegradability.