A case of lymphoepithelioma-like carcinoma of the skin associated with Epstein-Barr virus infection
A case of lymphoepithelioma-like carcinoma of the skin associated with Epstein-Barr virus infection
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DOI：
10.1016/j.jaad.2008.07.024
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发表时间：
2010-04-01
影响因子：
13.8
通讯作者：
Shimada, Shinji
中科院分区：
文献类型：
--
作者：
Aoki, Rui;Mitsui, Hiroshi;Shimada, Shinji
皮肤类上皮瘤癌是一种罕见的皮肤肿瘤，其组织病理学与鼻咽癌相似。鼻咽癌与EB病毒（EBV）的关联是有据可查的。据报道，EB病毒仅在四个部位（胃、唾液腺、肺和胸腺）与LELC相关，但在皮肤中不相关。我们在此报告一例EB病毒阳性LELCS。一位82岁女性，右脸颊有一红色结节。组织学上，整个真皮被非典型肿瘤细胞巢占据，伴密集的淋巴细胞浸润。肿瘤细胞的细胞角蛋白14呈强阳性，但细胞角蛋白19和20呈阴性。通过聚合酶链反应分析和原位杂交检测肿瘤细胞中的EBV基因组，提示与EBV相关。（J Am Acad Dermatol 2010;62：681-4.）
Lymphoepithelioma-like carcinoma of the skin (LELCS) is a rare cutaneous neoplasm with histopathologic similarities to nasopharyngeal carcinoma. The association of nasopharyngeal carcinoma with Epstein-Barr virus (EBV) is well documented. EBV has also been reported to be associated with LELC in only four sites (the stomach, salivary glands, lung, and thymus), but not in the skin. We report herein a case of EBV-positive LELCS. An 82-year-old female presented with a red nodule on the right cheek. Histologically, the entire dermis was occupied by atypical tumor cell nests with dense lymphocytic infiltration. Neoplastic cells were strongly positive for cytokeratin 14 but were negative for cytokeratins 19 and 20. EBV genomes in neoplastic cells were detected by polymerase chain reaction analysis and in situ hybridization for EBV-encoded RNA, suggesting an association with EBV. (J Am Acad Dermatol 2010;62:681-4.)