Development of effective living vaccines against bovine babesiosis - The longest field trial?
Development of effective living vaccines against bovine babesiosis - The longest field trial?
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DOI：
10.1016/s0020-7519(97)00034-9
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发表时间：
1997-07-01
影响因子：
4
通讯作者：
DeVos, AJ
中科院分区：
文献类型：
--
作者：
Callow, LL;Dalgliesh, RJ;DeVos, AJ
在1959至1996年间，澳大利亚进行了一项研究，以改变针对巴贝斯虫病的疫苗，并在实际或威胁到的不良现场反应变得明显时对其进行改进。最重大的变化发生在1964年，传统上使用的巴贝斯虫携带者被急性感染的脾切除小牛取代为疫苗捐赠者，这确保了疫苗的传染性，并幸运地与疫苗中牛巴贝斯虫的毒力降低有关。从那时起，布里斯班附近瓦科尔的实验室已经供应了2700多万剂高感染性疫苗。这种疫苗将澳大利亚接种巴贝斯虫病的牛的严重损失降低到非常低的水平，现在已在全世界得到接受。事实证明，确保疫苗持续有效的研究是至关重要的。(C)1997年澳大利亚寄生虫学学会。爱思唯尔科学有限公司出版。
Between 1959 and 1996, research was performed to change a vaccine against babesiosis in Australia and to improve it as actual or threatened untoward field responses became apparent. The most significant change occurred in 1964 with the traditionally used carriers of Babesia being replaced as vaccine donors by acutely infected splenectomised calves, This ensured the infectivity of the vaccine and was fortuitously associated with a reduction in the virulence of Babesia bovis in vaccine. Since then, mure than 27 million doses of highly infective vaccine have been supplied from the laboratory at Wacol near Brisbane. This vaccine reduced serious losses from babesiosis in vaccinated cattle Australia to very low levels and has now gained acceptance worldwide. Research to ensure the continuing effectiveness of the vaccine has proved to be essential. (C) 1997 Australian Society for Parasitology. Published by Elsevier Science Ltd.