Role of serum Ca, parathyroid hormone, and NaCl infusion on renal Ca and Na clearances.
Role of serum Ca, parathyroid hormone, and NaCl infusion on renal Ca and Na clearances.
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血清钙、甲状旁腺激素和氯化钠输注对肾钙和钠清除率的作用。
DOI：
10.1152/ajplegacy.1968.214.6.1403
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发表时间：
1968
期刊：
影响因子：
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通讯作者：
C. Kleeman
中科院分区：
文献类型：
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作者：
S. Massry;J. Coburn;L. W. Chapman;C. Kleeman
肖尔·马斯基杰克·W劳埃德·科伯恩Chapman，AND Charles R.克莱曼。serltm Ca、甲状旁腺激素和NaCl输注对肾脏Ca和Na清除率的作用。Am. J. Phvsiol. 214（6）：1403-1409。. 1968.-在15只接受不同顺序和速率的CaClz和/或NaCl输注的甲状腺甲状旁腺切除（T-PTX）犬中研究了血清钙和甲状旁腺激素（PTH）水平变化的影响，在一些犬中，研究了甲状旁腺提取物（PTE）。在T-PTX犬中，钙清除率（Co.）比钠清除率（C11）高4-6倍，CCn/CNa为5.10 = t0.94（平均值和SE）。PTE后Cca下降，Ces/CNa恢复正常。在CaClz输注过程中，钙和钠排泄增加，但在所有血清钙水平下，Cca不成比例地高于CNa。在钙输注期间，尽管GFR和滤过钠急性降低，但仍发生尿钠排泄。对低血钙正常的T-PTX犬输注生理盐水可使Co/C Na恢复正常。在高钙血症期间，高C_（11）/C_（11）不受盐水输注或PTE给药的影响。结果表明：1）PTH改变了Cclt和CNa之间的正常相互依赖性，2）在钙输注期间肾钠重吸收被抑制，和3）在高钙血症期间，增加的过滤钙或高细胞外或肾小管液钙浓度可能主要改变Ccn和CNn之间的关系。
MASSKY, SHAUL G., JACK W. COBURN, LLOYD W. CHAPMAN, AND CHARLES R. KLEEMAN. Role of serltm Ca, parathyroid hormone, and NaCl infusion on renal Ca and Na clearances. Am. J. Phvsiol. 214(6): 1403-1409. . 1968.-The effect of changes in serum calcium and parathyroid hormone (PTH) levels was studied in 15 thyroparathyroidectomized (T-PTX) dogs receiving CaClz and/or NaCl infusion in different sequences and rates and, in some, parathyroid extract (PTE). In T-PTX dogs calcium clearance (Co.) was 4-6 times greater than sodium clearance (C,,) with CCn/CNa of 5.10 =t 0.94 (mean & SE). After PTE, Cca fell and Ces/CNa returned to normal. During CaClz infusion both calcium and sodium excretion increased, but Cca was disproportionately higher than CNa at all levels of serum calcium. During calcium infusion natriuresis occurred despite acute reduction in GFR and filtered sodium. Saline infusion to hypoor normocalcemic T-PTX dogs restored Co, /C Na to normal. During hypercalcemia, the high C&,/C,, was not influenced by saline infusion or PTE administration. The results indicate that: 1) the normal interdependence between Cclt and CNa is altered by PTH, 2) renal sodium reabsorption is depressed during calcium infusion, and 3) during hypercalcemia, either increased filtered calcium or high extracellular or tubular fluid calcium concentration may primarily alter the relation between Ccn and C Nn-