CHEMOTHERAPY OF HUMAN CYSTIC ECHINOCOCCOSIS - COMPARATIVE EFFICACY OF MEBENDAZOLE AND ALBENDAZOLE
CHEMOTHERAPY OF HUMAN CYSTIC ECHINOCOCCOSIS - COMPARATIVE EFFICACY OF MEBENDAZOLE AND ALBENDAZOLE
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DOI：
10.1080/00034983.1992.11812631
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发表时间：
1992-02-01
影响因子：
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通讯作者：
NEDELKOV, G
中科院分区：
文献类型：
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作者：
TODOROV, T;VUTOVA, K;NEDELKOV, G
用甲苯咪唑与阿苯达唑治疗单、多、多器官包虫包虫51例，28例用甲苯咪唑50~70 mg·kg-1·d-1，疗程6~24个月，23例用白蛋白10 mg·kg-1·d-1，共4个疗程，疗程30天，疗程间隔15天。通过超声、计算机体层摄影和胸部X线片评价治疗效果。在评估结果时使用的标准是：“成功”，即对所有囊肿有效的证据；“部分成功”，即对某些囊肿有效的证据；以及“不成功”，即囊肿形态没有变化。MEB治疗成功8例(28.6%)，部分成功8例(28.6%)，失败12例(42.8%)。ALB治疗成功10例(43.5%)，部分成功10例(43.5%)，失败3例(13.0%)。
The relative efficacy of mebendazole (MEB) and albendazole (ALB) was tested by treating 51 patients with single, multiple and multi-organ hydatid cysts; 28 patients were treated with MEB, 50–70 mg kg−1body weight daily for six to 24 months, and 23 with ALB, 10 mg kg−1body weight daily in four courses of 30 days with 15-day intervals between courses. The therapeutic effect during the follow-up was assessed by ultrasonography, computerized tomography and chest X-ray. The criteria used when assessing the results were: ‘success’, evidence of effect on all cysts; ‘partial success’, evidence of effect on some of the cysts; and ‘no success’, no changes in cyst morphology. Treatment with MEB was successful in eight cases (28·6%), partially successful in eight (28·6%) and unsuccessful in 12 (42·8%). Treatment with ALB was successful in 10 cases (43·5%), partially successful in 10 (43·5%) and unsuccessful in three (13·0%).