Population pharmacokinetics of tacrolimus in umbilical cord blood transplant patients focusing on the variation in red blood cell counts
Population pharmacokinetics of tacrolimus in umbilical cord blood transplant patients focusing on the variation in red blood cell counts
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他克莫司在脐带血移植患者中的群体药代动力学重点关注红细胞计数的变化
DOI：
10.1111/jcpt.13279
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Sugioka N.
中科院分区：
文献类型：
--
作者：
Yoshida S;Fujimoto A;Fukushima K;Ando M;Irie K;Hirano T;Miyasaka M;Shimomura Y;Ishikawa T;Ikesue H;Muroi N;Hashida T;Sugioka N.
What is known and objectiveThe distribution of tacrolimus (TAC), an immunosuppressant used during cord blood transplantation (CBT)—one of the haematopoietic stem cell transplantations, to red blood cell (RBC) is approximately 90% in whole blood. In CBT patients, the total RBC count shows dramatic fluctuation due to conditioning before transplantation, including anticancer agents and total body irradiation, as well as RBC transfusions during the treatment period. Therefore, the amount of TAC in whole blood may show wide variation. However, therapeutic drug monitoring (TDM) of TAC has been performed based on the whole blood concentration. In this study, to contribute to TDM of TAC in CBT, we performed the population pharmacokinetic (PPK) analysis of TAC in 56 CBT patients and investigated the factors that affected the concentration of TAC, focusing the variation of RBC count.MethodA one‐compartment model was applied to the observed whole blood TAC concentrations, and a PPK analysis was conducted with a non‐linear mixed effect model.Results and discussionOur final PPK model indicated good robustness and accuracy. In addition, haemoglobin (Hb) level was an influential covariate on Vd, which was expressed as Vd(L) = 91.4 × (Hb/8.2)(−1.07).What is new and conclusionIn this study, our results showed the necessity for the Hb level monitoring during TDM of TAC in CBT patients and provided useful information for improving TDM strategy of TAC.
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FK 506 在移植患者中的药代动力学。
影响因子：
0.9
作者：
Venkataramanan,R;Jain,A;Warty,VS;Abu-Elmagd,K;Alessiani,M;Lever,J;Krajak,A;Flowers,J;Mehta,S;Zuckerman,S
通讯作者：
Zuckerman,S
影响因子：
158.5
作者：
Laughlin, MJ;Eapen, M;Horowitz, MM
通讯作者：
Horowitz, MM
DOI：
10.1182/asheducation-2015.1.454
发表时间：
2015-12-01
影响因子：
3
作者：
Liu, Chang;Grossman, Brenda J.
通讯作者：
Grossman, Brenda J.
影响因子：
4.3
作者：
Osunkwo, I;Bessmertny, O;Cairo, MS
通讯作者：
Cairo, MS
DOI：
10.1016/j.bbmt.2015.08.027
发表时间：
2016-02
期刊：
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
影响因子：
--
作者：
Khaled SK;Palmer JM;Herzog J;Stiller T;Tsai NC;Senitzer D;Liu X;Thomas SH;Shayani S;Weitzel J;Forman SJ;Nakamura R
通讯作者：
Nakamura R