The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes.
The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes.
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DOI：
10.1016/j.chom.2015.01.001
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发表时间：
2015-02-11
影响因子：
30.3
通讯作者：
Xavier RJ
中科院分区：
文献类型：
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作者：
Kostic AD;Gevers D;Siljander H;Vatanen T;Hyötyläinen T;Hämäläinen AM;Peet A;Tillmann V;Pöhö P;Mattila I;Lähdesmäki H;Franzosa EA;Vaarala O;de Goffau M;Harmsen H;Ilonen J;Virtanen SM;Clish CB;Orešič M;Huttenhower C;Knip M;DIABIMMUNE Study Group;Xavier RJ
胎儿和婴儿肠道微生物组的定植导致多样性的动态变化，这可能影响疾病的易感性。为了研究婴儿期人类肠道微生物群动力学与1型糖尿病（T1D）之间的关系，我们对33名遗传上易患T1D的婴儿进行了研究。通过婴儿期微生物丰度的建模轨迹揭示了大多数受试者共享的微生物关系的子集。虽然一个给定物种的菌株组成在个体之间是高度可变的，但在整个婴儿期，它在个体内部是稳定的。随着时间的推移，代谢成分和代谢途径丰度保持不变。在血清转化和T1D诊断之间的时间窗口中，观察到T1D进展者α多样性的显著下降，伴随着炎症有利生物体、基因功能、血清和粪便代谢物的峰值。这项工作确定了人类婴儿肠道微生物群的发展趋势，以及T1D发病前的特定改变，并区分了T1D进展者和非进展者。
Colonization of the fetal and infant gut microbiome results in dynamic changes in diversity, which can impact disease susceptibility. To examine the relationship between human gut microbiome dynamics throughout infancy and type 1 diabetes (T1D), we examined a cohort of 33 infants genetically predisposed to T1D. Modeling trajectories of microbial abundances through infancy revealed a subset of microbial relationships shared across most subjects. Although strain composition of a given species was highly variable between individuals, it was stable within individuals throughout infancy. Metabolic composition and metabolic pathway abundance remained constant across time. A marked drop in alpha-diversity was observed in T1D progressors in the time-window between seroconversion and T1D diagnosis, accompanied by spikes in inflammation-favoring organisms, gene functions, and serum and stool metabolites. This work identifies trends in the development of the human infant gut microbiome along with specific alterations that precede T1D onset and distinguish T1D progressors from non-progressors.