Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f.
Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f.
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DOI：
10.2165/00126839-200304010-00001
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发表时间：
2003-01-01
期刊：
影响因子：
3
通讯作者：
Kao, Peter N
中科院分区：
文献类型：
--
作者：
Qiu, Daoming;Kao, Peter N
雷公藤提取物。F.（雷公藤，雷公藤）是有效的传统中药用于治疗免疫炎症性疾病，包括类风湿性关节炎，系统性红斑狼疮，肾炎和哮喘。雷公藤提取物中存在的萜类化合物的特征鉴定了雷公藤内酯醇，一种二萜类化合物三环氧化物，负责体外观察到的大多数免疫抑制，抗炎和抗增殖作用。雷公藤内酯醇在转录水平抑制淋巴细胞活化和T细胞白细胞介素-2的表达。在所有检查的细胞类型中，雷公藤内酯醇在与DNA结合后在细胞核中的一个独特步骤抑制核因子-κ B转录激活。雷公藤内酯醇作用的分子机制的进一步表征将有助于阐明免疫系统调节的途径。
Extracts of Tripterygium wilfordii hook. f. (leigong teng, Thundergod vine) are effective in traditional Chinese medicine for treatment of immune inflammatory diseases including rheumatoid arthritis, systemic lupus erythematosus, nephritis and asthma. Characterisation of the terpenoids present in extracts of Tripterygium identified triptolide, a diterpenoid triepoxide, as responsible for most of the immunosuppressive, anti-inflammatory and antiproliferative effects observed in vitro. Triptolide inhibits lymphocyte activation and T-cell expression of interleukin-2 at the level of transcription. In all cell types examined, triptolide inhibits nuclear factor-kappaB transcriptional activation at a unique step in the nucleus after binding to DNA. Further characterisation of the molecular mechanisms of triptolide action will serve to elucidate pathways of immune system regulation.