The effect of mind-body and aerobic exercise on negative symptoms in schizophrenia: A meta-analysis
The effect of mind-body and aerobic exercise on negative symptoms in schizophrenia: A meta-analysis
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DOI：
10.1016/j.psychres.2019.03.012
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发表时间：
2019-03
影响因子：
11.3
通讯作者：
J. S. Vogel;M. van der Gaag;C. Slofstra;H. Knegtering;J. Bruins;S. Castelein
中科院分区：
文献类型：
--
作者：
J. S. Vogel;M. van der Gaag;C. Slofstra;H. Knegtering;J. Bruins;S. Castelein
目的探讨不同类型体育锻炼对精神分裂症患者阴性症状的影响。对心身运动(MBE)、有氧运动(AE)和耐力训练(RT)进行研究。方法检索Cochrane图书馆、Medline、Embase和QicINFO，直至2018年4月26日。在对阴性症状进行评估后，纳入了对精神分裂症患者进行PE与任何对照组的随机对照试验。这项荟萃分析是根据PRISMA指南进行的。采用Cochrane偏差风险评估工具对纳入研究的方法学质量进行评估。结果共纳入22篇研究(N= 1249)。总体方法学质量较差。Meta分析(随机效应模型)显示，与任何对照条件相比，任何PE干预(Hedges‘g= 0.434，95%CI=0.196-0.671)都有中等显著的效果。在任何对照条件下，MBE和AE分别表现出中等显著效应(Hedges‘g= 0.461)和小显著效应(Hedgees’g= 0.341)。RT的效果无法检测。总体异质性很高(I2=0.76%)，不能通过调节或敏感性分析来降低。结论这一荟萃分析表明PE可以作为治疗阴性症状的一种有前途的干预措施。然而，纳入的研究质量低，异质性高，因此无法做出明确的推荐。因此，对结果的解读应该谨慎。
ObjectiveThis meta-analysis aims to evaluate the effects of different types of physical exercise (PE) on negative symptoms in schizophrenia patients. Mind-body exercise (MBE), aerobic exercise (AE) and resistance training (RT) will be investigated.MethodThe Cochrane Library, Medline, Embase and PsycINFO were searched from their inception until April 26, 2018. Randomized controlled trials comparing PE with any control group in patients with schizophrenia were included when negative symptoms had been assessed. This meta-analysis was conducted according to the PRISMA guidelines. The methodological quality of the included studies was assessed with the Cochrane Risk of Bias assessment tool. Moderator, sensitivity, and meta regression analyses were conducted to explore causes of heterogeneity and impact of study quality.ResultsWe included 22 studies (N= 1249). The overall methodological quality was poor. The meta-analysis (random effects model) showed a medium significant effect in favor of any PE intervention (Hedges’g= 0.434, 95% CI = 0.196–0.671) versus any control condition. MBE and AE respectively showed a medium significant effect (Hedges’g= 0.461) and a small significant effect (Hedges’g= 0.341) versus any control condition. The effect of RT could not be examined. The overall heterogeneity was high (I2= 76%) and could not be reduced with moderator or sensitivity analyses.ConclusionThis meta-analysis demonstrated that PE could be a promising intervention in the treatment of negative symptoms. However, the quality of the included studies was low and heterogeneity was high, which makes it impossible to make a clear recommendation. Therefore, results should be interpreted with care.