One-Step Protein–Polymer Conjugates from Boronic-Acid-Functionalized Polymers
One-Step Protein–Polymer Conjugates from Boronic-Acid-Functionalized Polymers
复制标题
来自硼酸功能化聚合物的一步蛋白质-聚合物缀合物
DOI：
10.1021/acs.bioconjchem.0c00516
复制
发表时间：
2020
影响因子：
4.7
通讯作者：
Ball, Zachary T.
中科院分区：
文献类型：
--
作者：
Swierczynski, Michael J.;Ball, Zachary T.
聚合物-蛋白质偶联物是一种具有有趣和有用性质的杂化材料。制备这类不同二嵌段材料的方法通常难以处理试剂的复杂性和尺寸，因此聚合物-蛋白质缀合代表了非传统生物缀合方法（如金属催化芳基化）的严格测试基础。这项工作证明了一个简单的镍2+促进芳基化的半胱氨酸残基与末端官能化的聚合物-硼酸试剂，并探讨了一些分子和物理性质可能在这些混合结构。
Polymer–protein conjugates are hybrid materials with interesting and useful properties. Methods to prepare diverse diblock materials of this sort often struggle to deal with the complexity and size of reagents, and so polymer–protein conjugation represents a stringent testing ground for nontraditional bioconjugation methods, such as metal-catalyzed arylation. This work demonstrates a simple Ni2+-promoted arylation of cysteine residues with end-functionalized polymer−boronic acid reagents, and explores some molecular and physical properties possible in these hybrid structures.