Role of transmitters in mediating hypothalamic control of electrolyte excretion.
Role of transmitters in mediating hypothalamic control of electrolyte excretion.
复制标题
递质在介导下丘脑控制电解质排泄中的作用。
DOI：
10.1139/y77-157
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发表时间：
1977
影响因子：
2.1
通讯作者：
R. Orías
中科院分区：
文献类型：
--
作者：
M. Morris;S. Mccann;R. Orías
在清醒雄性大鼠的第三脑室注射胆碱能和单胺能药物后，监测尿量和电解质排泄的变化，通过静脉输注5%葡萄糖进行利尿。脑室内注射去甲肾上腺素（NE）或卡巴胆碱可引起利钠利尿反应，而多巴胺（DA）则无此作用。β-受体刺激剂异丙肾上腺素（ISO）诱导抗心房利尿和抗钾尿作用。脑室内注射α-肾上腺素能受体阻滞剂酚妥拉明可阻断NE和卡巴胆碱以及脑室内高渗盐水（HS）的利钠反应。相比之下，β-肾上腺素能受体阻滞剂普萘洛尔单独注射时引起尿钠排泄和尿钾排泄，注射NE或HS后产生叠加效应。普萘洛尔增强了对卡巴胆碱的利钠反应。用阿托品阻断胆碱能可减弱对NE的反应，并阻断对HS的利钠反应。这表明，心室壁中的钠受体可以通过涉及胆碱能和α-肾上腺素能受体的刺激途径来改变肾钠排泄，并且可以通过具有张力活性的β-受体途径来抑制钠排泄。
Changes in urinary volume and electrolyte excretion were monitored after the injection of cholinergic and monoaminergic drugs into the third cerebral ventricle of conscious male rats made diuretic by an intravenous infusion of 5% dextrose. A natriuretic and kaliuretic response was induced by the intraventricular injection of norephrine (NE) or carbachol, whereas dopamine (DA) had no effect. The beta-receptor stimulator isoproterenol (ISO) induced an antinatriuretic and antikaliuretic effect. Intraventricular injection of the alpha-adrenergic blocker phentolamine abolished the natriuretic response to NE and carbachol and to intraventricular hypertonic saline (HS). By contrast, the beta-adrenergic blocker propranolol induced a natriuresis and kaliuresis when injected alone and an additive effect when its injection was followed by NE or HS. Propranolol potentiated the natriuretic response to carbachol. Cholinergic blockade with atropine diminished the response to NE and blocked the natriuretic response to HS. It is suggested that sodium receptors in the ventricular wall can modify renal sodium excretion via a stimulatory pathway involving cholinergic and alpha-adrenergic receptors and can inhibit sodium excretion via a tonically active beta-receptor pathway.