Isolated myocyte contractile function is normal in postinfarct remodeled rat heart with systolic dysfunction
Isolated myocyte contractile function is normal in postinfarct remodeled rat heart with systolic dysfunction
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DOI：
10.1161/01.cir.96.11.3974
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发表时间：
1997-12-02
期刊：
影响因子：
37.8
通讯作者：
Chandrashekhar, Y
中科院分区：
文献类型：
--
作者：
Anand, IS;Liu, DS;Chandrashekhar, Y
梗死后心室重构与远端非梗死心肌的延长和收缩功能障碍有关。这种现象的机制尚不清楚。方法和结果我们研究了一系列的变化，在全球左心室（LV）的结构和功能在梗死（1，2，4，6周后心肌梗死）和假手术大鼠心脏和相关的结构和功能变化的心肌细胞分离的远程LV心肌在同一心脏。心肌梗死大鼠出现明显的重构。心脏重量/体重比增加。充盈压为10 mm Hg时的左心室容积较高（305+/-28对215+/-12 μ L，P
Background Postinfarction ventricular remodeling is associated with lengthening and contractile dysfunction of the remote noninfarcted myocardium. Mechanisms underlying this phenomenon remain unclear.Methods and Results We studied serial changes in global left ventricular (LV) structure and function in infarcted (1, 2, 4, and 6 weeks after myocardial infarction) and sham-operated rat hearts and correlated them with structural and functional changes in myocytes isolated from the remote LV myocardium in the same hearts. Rats with myocardial infarction developed significant remodeling. The heart weight-to-body weight ratios were increased. LV volumes at filling pressure of 10 mm Hg were higher (305+/-28 versus 215+/-12 mu L, P