A Sco homologue plays a role in defence against oxidative stress in pathogenic Neisseria.
A Sco homologue plays a role in defence against oxidative stress in pathogenic Neisseria.
复制标题
Sco 同源物在防御致病性奈瑟菌氧化应激中发挥作用。
DOI：
10.1016/s0014-5793(03)00632-x
复制
发表时间：
2003
期刊：
影响因子：
3.5
通讯作者：
McEwan,AlastairG
中科院分区：
文献类型：
--
作者：
Seib,KateL;Jennings,MichaelP;McEwan,AlastairG
Sco proteins are found in mitochondria and in a variety of oxidase positive bacteria. Although Sco is required for the formation of the CuAcentre in a cytochrome oxidase of the aa3type, it was observed that oxidases with a CuAcentre are not present in many bacteria that contain a Sco homologue. Two bacteria of this type are the pathogens Neisseria meningitidis and Neisseria gonorrhoeae. The sco genes of N. gonorrhoeae strain 1291 and N. meningitidis strain MC58 were cloned, inactivated by inserting a kanamycin resistance cassette and used to make knockout mutants by allelic exchange. Both N. gonorrhoeae and N. meningitidis sco mutants were highly sensitive to oxidative killing by paraquat, indicating that Sco is involved in protection against oxidative stress in these bacteria.
