Chemical Constituents of a Marine Fungus, Arthrinium sacchari
Chemical Constituents of a Marine Fungus, Arthrinium sacchari
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DOI：
10.1021/np200108h
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发表时间：
2011-07-01
影响因子：
5.1
通讯作者：
Koyama, Kiyotaka
中科院分区：
文献类型：
--
作者：
Tsukada, Mariko;Fukai, Miyuki;Koyama, Kiyotaka
从海洋真菌Arthrinium sacchari中分离得到三个新的二萜化合物myrocin D（1）、libertellenone E（2）和libertellenone F（3），和一个新的异香豆素decarboxyhydroxycitrinone（4），以及三个已知化合物（5-7）。化合物1-4的结构经核磁共振谱、质谱、红外光谱确证，化合物1-3的绝对构型经X-射线衍射分析确定。通过测量这些化合物对人脐静脉内皮细胞（HUVECs）和人脐动脉内皮细胞（HUAECs）的抗增殖作用来评价它们的抗血管生成活性。化合物4-7显示出抑制活性。
Three new diterpenes, myrocin D (1), libertellenone E (2), and libertellenone F (3), and a new isocoumarin, decarboxyhydroxycitrinone (4), were isolated from the marine fungus Arthrinium sacchari, together with three known compounds (5-7). The structures of 1-4 were elucidated from spectroscopic data (NMR, MS, IR), and the absolute configurations of 1-3 were determined by X-ray diffraction analysis. The antiangiogenic activity of these compounds was evaluated by measuring their antiproliferation effects on human umbilical vein endothelial cells (HUVECs) and human umbilical artery endothelial cells (HUAECs). Compounds 4-7 showed inhibitory activity.