Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities.
Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities.
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DOI：
10.1038/s41467-021-22140-0
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发表时间：
2021-03-25
影响因子：
16.6
通讯作者：
Maura F
中科院分区：
文献类型：
--
作者：
Oben B;Froyen G;Maclachlan KH;Leongamornlert D;Abascal F;Zheng-Lin B;Yellapantula V;Derkach A;Geerdens E;Diamond BT;Arijs I;Maes B;Vanhees K;Hultcrantz M;Manasanch EE;Kazandjian D;Lesokhin A;Dogan A;Zhang Y;Mikulasova A;Walker B;Morgan G;Campbell PJ;Landgren O;Rummens JL;Bolli N;Maura F
Multiple myeloma (MM) is consistently preceded by precursor conditions recognized clinically as monoclonal gammopathy of undetermined significance (MGUS) or smoldering myeloma (SMM). We interrogate the whole genome sequence (WGS) profile of 18 MGUS and compare them with those from 14 SMMs and 80 MMs. We show that cases with a non-progressing, clinically stable myeloma precursor condition (n = 15) are characterized by later initiation in the patient’s life and by the absence of myeloma defining genomic events including: chromothripsis, templated insertions, mutations in driver genes, aneuploidy, and canonical APOBEC mutational activity. This data provides evidence that WGS can be used to recognize two biologically and clinically distinct myeloma precursor entities that are either progressive or stable. The factors that are associated with myeloma precursor condition progression are not well understood. Here the authors find that monoclonal gammopathies of undetermined significance and smoldering myelomas that did not progress to multiple myelomas have a distinct genomic profile and emerge later in the patient’s life.
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影响因子：
20.3
作者：
Dhodapkar, Madhav V.;Sexton, Rachael;Barlogie, Bart
通讯作者：
Barlogie, Bart
影响因子：
30.8
作者：
Chan K;Roberts SA;Klimczak LJ;Sterling JF;Saini N;Malc EP;Kim J;Kwiatkowski DJ;Fargo DC;Mieczkowski PA;Getz G;Gordenin DA
通讯作者：
Gordenin DA
影响因子：
45.3
作者：
Bustoros, Mark;Sklavenitis-Pistofidis, Romanos;Ghobrial, Irene M.
通讯作者：
Ghobrial, Irene M.
影响因子：
14.8
作者：
Ellis, Peter;Moore, Luiza;Campbell, Peter J.
通讯作者：
Campbell, Peter J.
影响因子：
64.8
作者：
Lee-Six, Henry;Olafsson, Sigurgeir;Stratton, Michael R.
通讯作者：
Stratton, Michael R.