Associating resting-state connectivity with trait impulsivity.
Associating resting-state connectivity with trait impulsivity.
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DOI：
10.1093/scan/nsx031
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发表时间：
2017-06-01
影响因子：
4.2
通讯作者：
Vickery TJ
中科院分区：
文献类型：
--
作者：
Angelides NH;Gupta J;Vickery TJ
心理测量学研究已经确定了稳定的特征，预测个体间的差异，在食欲动机和方法的行为。行为抑制系统/行为激活系统（BIS/BAS）量表已被开发，以定量评估这些性状。然而，在BIS/BAS中反映的建议结构对应的神经机制仍然定义不清。腹侧纹状体（VS）和眶额皮质（OFC）涉及subserving奖励相关的功能，也与BAS。在这项研究中，我们研究了这些区域之间的功能连接是否可以预测这些尺度的组成部分。我们采用静息状态功能连接和BIS/BAS评分评估人格问卷。参与者完成了一个休息状态运行和行为抑制和激活系统（BIS/BAS）问卷。使用静息状态BOLD，我们评估了两个基底神经节ROI（尾状核和壳核）和双侧OFC ROI之间的相关性，建立了单个受试者连接汇总评分。总分与BIS/BAS评分的组成部分相关。结果表明，一种新的相关性BAS乐趣寻求和中间OFC和壳核之间的休息状态连接，这意味着奖励处理区域之间的自发同步可能发挥作用，在定义与冲动性相关的人格特征。
Psychometric research has identified stable traits that predict inter-individual differences in appetitive motivation and approach behavior. Behavioral Inhibition System/Behavioral Activation System (BIS/BAS) scales have been developed to quantitatively assess these traits. However, neural mechanisms corresponding to the proposed constructs reflected in BIS/BAS are still poorly defined. The ventral striatum (VS) and orbitofrontal cortex (OFC) are implicated in subserving reward-related functions that are also associated with the BAS. In this study, we examined whether functional connectivity between these regions predicts components of these scales. We employed resting-state functional connectivity and BIS/BAS scores assessed by a personality questionnaire. Participants completed a resting state run and the Behavioral Inhibition and Activation Systems (BIS/BAS) Questionnaire. Using resting-state BOLD, we assessed correlations between two basal ganglia ROIs (caudate and putamen) and bilateral OFC ROIs, establishing single subject connectivity summary scores. Summary scores were correlated with components of BIS/BAS scores. Results demonstrate a novel correlation between BAS-fun seeking and resting-state connectivity between middle OFC and putamen, implying that spontaneous synchrony between reward-processing regions may play a role in defining personality characteristics related to impulsivity.