Total Synthesis and Structural Revision of Antibiotic CJ-16,264.
Total Synthesis and Structural Revision of Antibiotic CJ-16,264.
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DOI：
10.1002/anie.201504337
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发表时间：
2015-08-03
期刊：
影响因子：
--
通讯作者：
Theodorakis EA
中科院分区：
文献类型：
--
作者：
Nicolaou KC;Shah AA;Korman H;Khan T;Shi L;Worawalai W;Theodorakis EA
报道了抗生素CJ-16，264的全合成及结构修正。从香茅醛开始，对目标分子的探索以一种新的双跨环Diels-Alder反应为特色，该反应立体选择性地铸造了十氢萘系统，并包括在其真实结构的神秘化之前合成六种异构体。
The total synthesis and structural revision of antibiotic CJ-16,264 is described. Starting with citronellal, the quest for the target molecule featured a novel bis-transannular Diels–Alder reaction that casted stereoselectively the decalin system and included the synthesis of six isomers before demystification of its true structure.